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Colchicine for Prevention of Postpericardiotomy Syndrome and Postoperative Atrial Fibrillation

Sunday, September 7, 2014

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Author(s)

Massimo Imazio and others for the COPPS-2 Investigators

The COPPS-2 trial evaluated the efficacy of oral colchicine in reducing a-fib, post-pericardiotomy syndrome, and pericardial/pleural effusion after cardiac surgery in 360 pts randomized to drug or placebo for 1 month postop.  Colchicine reduced the incidence of post-pericardiotomy syndrome (20% vs 30%) but had no important effect on effusions or a-fib.  Adverse events were more common in the Colchicine group (20% vs 12%).

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