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Journal and News Scan
When she was four months old, doctors determined that Bryce would need heart surgery as soon as possible. Though she was in the 50th percentile for weight when she was born, Bryce had sunk to below zero.
Her cardiologist brought in Khanh H. Nguyen of Maria Fareri Children’s Hospital who performs a unique form of open-heart surgery, where the incision is made under the armpit, rather than the traditional method of sternotomy. Dr Nguyen started using this different approach 14 years ago.
This is a fabulous video of a miniAVR with a right thoracotomy that is only 3 cm in size and hardly could fit the valve through it!
Professor Yan used a series of specialised instruments, a corknot, and an endoscope to achieve this fantastic result.
The Doodle Factory, an Egyptian brand that combines art and charity, has launched a new collection to fund heart surgeries for two children.
Premium cigar makers in the US are launching a second bid to convince the US Food and Drug Administration (FDA) to exempt their products from a previous expansion of tobacco regulations.
The cardiac surgery program at the University of Arkansas for Medical Sciences has been suspended while the program recruits a replacement for its lead surgeon, who retired.
Drugs and Devices
The US FDA has approved Andexxa from Portola, an antidote for factor Xa inhibiting blood thinners, and the company expects to launch the drug in June.
The US FDA is seeking permanent injunctions against two stem cell clinics for deviations from good manufacturing practices and for marketing stem cell products to patients without FDA approval. The clinics were said to have been administering stem cells for the experimental treatment of cancers, heart disease, and chronic obstructive pulmonary disease, among other conditions.
Research, Trials, and Funding
Researchers in the US find that women are proportionately represented in clinical trials for hypertension and atrial fibrillation but underrepresented in trials for coronary artery disease and acute coronary syndrome.
Researchers in Sweden published research suggesting that lung cancer surgery outcomes are not affected by the day of the week that the surgery is performed.
An international group of researchers from Italy, the US, and the UK described disparities in lung cancer care between England and the US, finding that fewer patients in England present with early stage lung cancer and fewer English patients with stage I disease undergo surgery.
Awori and colleagues reviewed 19 published studies on repair of tetralogy of Fallot (TOF), representing 2,500 patients of which 54.8% had a transannular patch (TAP) inserted to relieve right ventricular outflow tract obstruction. The measured pulmonary annulus size, expressed as a z-score, is often used to determine when to insert a TAP, however similar z-scores derived via different methods can represent different annulus sizes and flow rates. Multiple suggested z-score “cut-offs” are quoted in the literature, and the authors wanted to know whether differences in z-score calculation methods were related to these different cut-off values. Surprisingly few studies (26.3%) mention what pulmonary annulus size “cut-off” was used, but the authors conclude that derivation of z-scores from different data sets may contribute to different cut-off values.
The authors have used a number of novel kidney related biomarkers to improve the identification of patients with acute kidney injury (AKI) and its likely progression. This is an important issue in cardiac surgery, as the outcomes after significant kidney injury can be quite devastating. If we can improve on watching creatinine changes, we can then look at interventions which may reduce the incidence or severity of AKI.
Shroyer and colleagues evaluated observed-to-expected outcome ratios for 30-day operative mortality and major morbidity across over 540,000 nonemergent first-time coronary artery bypass graft (CABG) procedures in The Society for Thoracic Surgeons Adult Cardiac Surgery Database. Given the increasing number of US health care system mergers and the decreasing proportion of cardiothoracic surgeons in private practice, the authors sought to determine whether risk-adjusted CABG outcomes varied based on the number of centers at which a surgeon operates. They found that observed-to-expected mortality ratios were better for single-center than for multicenter surgeons (0.97, 95% CI 0.94-1.00, versus 1.06, 95% CI 1.01-1.12), and that ratios for multicenter surgeons were better at their primary hospital (1.01, 95% CI 0.96-1.07) than at their satellite facilities (1.17, 95% CI 1.09-1.27).
This systematic review by Udelsman and colleagues assesses the clinical successes and setbacks of the current methods of airway replacement. Twenty-one studies, focusing primarily on the clinical translation of circumferential or near circumferential tracheal substitutes, were included in the final assessment. A total of 41 patients were identified as having received allotransplantation, autologous tissue reconstruction, bioprosthetic reconstruction, or tissue engineered reconstruction between January 2000 and October 2017. The authors conclude that each modality has its unique advantages and disadvantages; however, no clear ideal prosthetic or graft material stands out at present. Further laboratory work is required before tracheal substitutes, particularly tissue engineered conduits, are more widely utilized.
Patient Care and General Interest
An article in the New York Times looks at the ethical dilemma of performing surgery for endocarditis in illicit drug users whose addictions go untreated.
ERAS® Cardiac Surgery presented an expert consensus statement on best practices to speed recovery at the Enhanced Recovery After Cardiac Surgery session at the recent AATS Annual Meeting in San Diego, California.
Drugs and Devices
The Australian Research Council Research Hub for Advanced Manufacturing of Medical Devices has been launched at the University of Queensland as part of an initiative to drive innovation by supporting collaborative research between academic and industry groups.
The Cardioband transcatheter tricuspid valve reconstruction system from Edwards Lifesciences has received CE Mark approval.
Research, Trials, and Funding
Terumo Aortic has launched an early feasibility study to evaluate the safety and efficacy of its RelayBranch thoracic stent-graft system.
Research presented at the recent AATS Annual Meeting suggests that the likelihood of upstaging increases with each week between staging and surgery for non-small cell lung cancer, which supports sooner surgery to avoid cancer progression and improve the likelihood of curative resection.
A detailed well-referenced update on cardiovascular biomarkers, included in a compendium issue of the periodical.
The concept of ventricular mural antagonism has been introduced recently, where the main constrictive forces in the ventricular myocardium are complemented by a dilatory force component. Lunkenheimer and colleagues provide evidence for the radial force underlying this dilatory component, and they highlight its role in healthy and diseased myocardium.