The Impact of Restricted Chests on Long-Term Lung Function Parameters Following Lung Transplantation in Patients With Interstitial Lung Disease [1]
This study explores how disparities between actual and predicted total lung capacity (TLC) in patients with interstitial lung disease (ILD) affect lung function parameters and long-term outcomes after lung transplantation. A total of 170 ILD patients who underwent lung transplantation between 2011 and 2022 were included. They were stratified based on the preoperative median ratio of recipient actual to predicted (a/p) TLC. Of these, 85 patients had a low a/p TLC ratio corresponding to <0.55, while the remaining 85 patients had a high a/p TLC ratio of ≥0.55. There were no significant differences between the two groups in tracheostomy and reintubation rates, mechanical ventilation duration, ICU and hospital stays, or five-year overall survival. Although early post-LTx lung function was better in the high a/p TLC ratio group, long-term outcomes were similar in both groups. These findings may suggest remodeling of chest wall compliance in severely restricted ILD patients after LTx.