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Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer

Tuesday, June 11, 2019

Submitted by

Mark Ferguson

Source

Source Name: JACC

Source URL: http://www.onlinejacc.org/content/73/23/2976

Author(s)

Katelyn M. Atkins, Bhupendra Rawal, Tafadzwa L. Chaunzwa, Nayan Lamba, Danielle S. Bitterman, Christopher L. Williams, David E. Kozono, Elizabeth H. Baldini, Aileen B. Chen, Paul L. Nguyen, Anthony V. D’Amico, Anju Nohria, Udo Hoffmann, Hugo J.W.L. Aerts, Raymond H. Mak

In this retrospective review of the effects of radiation dose to the heart on long-term outcomes, 748 patients with regionally advanced non–small cell lung cancer were studied. An increasing cardiac radiotherapy dose was associated with an increased risk of MACE and all-cause mortality. This was observed primarily in patients without preexisting heart disease.