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Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes

Thursday, August 31, 2023

Submitted by

Aristotle Protopapas

Source

Source Name: Circulation Research

Source URL: https://www.ahajournals.org/doi/epdf/10.1161/CIRCRESAHA.123.322590

Author(s)

Konstantinos Theofilatos, Stefan Stojkovic, Maria Hasman, Sander W. van der Laan, Ferheen Baig, Javier Barallobre-Barreiro, Lukas Schmidt, Siqi Yin, Xiaoke Yin, Sean Burnap, Bhawana Singh, Jude Popham, Olesya Harkot, Stephanie Kampf, Maja Carina Nackenhorst, Andreas Strassl, Christian Loewe, Svitlana Demyanets, Christoph Neumayer, Martin Bilban, Christian Hengstenberg, Kurt Huber, Gerard Pasterkamp, Johann Wojta, Manuel Mayr

This is an open access genomic study of carotid atheroma in Viennese patients with a useful extensive discussion on potential translational value of the signature of calcification, juxtaposed to sonographic diagnostics and in the quest to manage the risk of rupture of carotid atheromatous plaque. The article also has gravitas in the light of the updated ESVS guidelines in carotid disease.