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Methylprednisolone for Heart Surgery in Infants—A Randomized, Controlled Trial

Thursday, December 15, 2022

Submitted by

Cameron Lind

Source

Source Name: The New England Journal of Medicine

Source URL: https://www.nejm.org/doi/full/10.1056/NEJMoa2212667

Author(s)

Kevin D. Hill, M.D., M.S.C.I., Prince J. Kannankeril, M.D., M.S.C.I., Jeffrey P. Jacobs, M.D., H. Scott Baldwin, M.D., Marshall L. Jacobs, M.D., Sean M. O’Brien, Ph.D., David P. Bichel, M.D., Eric M. Graham, M.D., Brian Blasiole, M.D., Ph.D., Ashraf Resheidat, M.D., Adil S. Husain, M.D., S. Ram Kumar, M.D., Ph.D., et al., for the STRESS Network Investigators

The outcome of perioperative prophylactic glucocorticoids for heart surgery in infants was unknown, and this study aimed to determine the effectiveness using a multicenter, randomized trial. Out of the infants who received either a dose of methylprednisolone or a placebo, the likelihood of a worse outcome did not significantly differ.