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Ross Procedure Using the Right Atrial Appendage Valve Instead of a Homograft: An All-Native Valve Approach

Tuesday, April 22, 2025

Ali Amirghofran A, Rafati Navaei M. Ross Procedure Using the Right Atrial Appendage Valve Instead of a Homograft: An All-Native Valve Approach. April 2025. doi:10.25373/ctsnet.28840751

The Ross procedure has demonstrated excellent mid- and long-term outcomes (1), establishing it as the preferred aortic valve replacement for young patients in many centers. However, its primary limitation remains the reliance on a homograft in the pulmonary position, which frequently necessitates future reinterventions. This raises a critical question: Can a native tissue valve be used in the pulmonary position to delay or even eliminate the need for repeat procedures? 
 
Since 2018, the authors have employed the right atrial appendage (RAA) valve in both pulmonary and tricuspid positions. A step-by-step instructional video titled “How to Make a Valve for the RVOT from the Right Atrial Appendage”  is available on CTSNet, providing a step-by-step guide on RAA valve construction (2). Encouraged by promising mid-term results, the authors have refined their technique to integrate the RAA valve into Ross and Ross-Konno procedures. This video illustrates a modified approach for the Ross procedure in young and adult patients. 
In this 16-year-old patient, the surgeons harvested and prepared the RAA using the previously described technique for patients with tetralogy of Fallot. The surgeons modified the technique by constructing the RAA valve inside a Gore-Tex tube, creating a "T-RAA valve." This valved conduit functions similarly to a homograft and can be used in any scenario requiring a homograft in young or adult-sized patients, including Ross and Ross-Konno procedures or pulmonary atresia repair. 
 
Due to the fixed structure of the annulus and commissures, the surgeons do not anticipate changes in the valve’s geometry over time. Additionally, the living native tissue of the leaflets eliminates the long-term risks of degeneration or calcification. However, this technique can only be used when an adult-sized tube graft is appropriate, as the tube cannot dilate or grow. 
 
The 20 mm Gore-Tex tube used in this technique is the same as those employed in extracardiac total cavopulmonary connections (TCPC) patients for many years, with no signs of calcification or stenosis in long-term studies. Therefore, the authors expect this valved conduit to remain durable while preserving the option for future catheter-based valve reintervention if needed. 
 
Immediate and early echocardiographic studies confirmed excellent function of both the autograft and the T-RAA valve. 
 
For small children, where growth potential must be preserved, the surgeons avoided a fixed-size tube. Instead, they created a native posterior wall for the right ventricle-to-pulmonary artery (RV-to-PA) pathway using a piece of autologous ascending aorta—a technique that will be demonstrated in a separate video.  


References

  1. Aboud, A., Charitos, E. I. Fujita, B., Stierle, U., Reil, J. C., Voth, V... & Ensminger, S. (2021). Long-term results of undergoing the Ross procedure. Journal of the American College of Cardiology, 77(11), 1412-1422.
  2. Amirghofran AA. How to Make a Valve for the RVOT from the Right Atrial Appendage. Ctsnet.org. Published online October 19, 2022. doi:https://doi.org/10.25373/ctsnet.21354825.v1

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Comments

Very inquisitive and practical solution to a difficult problem. What about using autologous pericardium to form the tube? I would be looking forward to learn about growth potential and long term durability. Again, very stimulating!
Many thanks for your comment. I guess using the Gore-Tex tube will be more stable in long term as this tube has been used for years in extracardiac TCPC patients . The pericardial tube may be less predictable and may shrink or dilate and this may change the geometry of the RAA valve affecting its function. The RAA valve itself seems to have potential for growth although this will be limited by the Gore-tex tube. However growth potentiall in this case is not needed as the 20 mm diameter may be enough for an adult paltient. We are following these patients for long time durability and certalinly we will report the long term follow up. Thanks again.
Great alternative! I wonder if you could performed the RAA dissection and the creation of the new pulmonic composite graft either off-pump or on-pump beating heart to decrease the cross-clamp time. Thanks
Many thanks for your nice comment. This is a useful and attractive alternative. However we have never dond harvesting the RAA without cardioplegic arrest as I think it may be more difficult to do the elongation maneuver of releasing the medial attachments of the RAA on beating heart, which may lead to have shorter RAA valves. Of course in cases who already have nice tall appendages it will certainly be a good option. Thanks again.
HI Very interesting technical response to an old issue by the time of any first operation. Did you have any Redo cases when the RAA was already cannulated by the time of the prior operation?
HI, Thanks for your prompt reply At least in the domaines to congenital and adult congenital surgery, it should be envisaged and encouraged to change venous cannulation paradigms as to preserve the RAA structural integrity in view of further using RAA as described herein. This alternative venous cannulation can be advanced: https://doi.org/10.14503/THIJ-14-4983 Cordially
Dear Dr Rahman. We think the intimal proliferation and overgroth is more with the Dacron graft which may jeopardize the valve function. This is mostly based on the experience with using the GoreTex tube in TCPC patients. Thanks

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