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Journal and News Scan

Source: NewYork-Presbyterian Hospital
Author(s): NewYork-Presbyterian Hospital Staff

After enduring cardiopulmonary bypass, many patients experience an inflammatory response, which can lead to prolonged ventilation, bleeding, stroke, and renal dysfunction. The NewYork-Presbyterian and Weill Cornell Medicine trial center was chosen to further investigate RBT-1 to see if it can help the production of anti-inflammatory cytokines and reduce the occurrence of common post-surgical complications. Researchers found that patients who received RBT-1 had a 46 percent decrease in blood product transfusions, a lower likelihood of readmission to the hospital within 30 days, and spent less time in the ICU and on a ventilator.

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Carolyn Weber, Martin Misfeld, Mahmoud Diab, Shekhar Saha, Ahmed Elderia, Mateo Marin-Cuartas, Maximilian Luehr, Ayla Yagdiran, Peer Eysel, Norma Jung, Christian Hagl, Torsten Doenst, Michael A Borger, Nikolaus Kernich, Thorsten Wahlers

This retrospective multicentric study aimed to analyze the impact of the sequence of surgical treatment of concomitant infective endocarditis and spondylodiscitis on postoperative outcomes. Of a total of 3,991 patients with infective endocarditis, 150 patients (4.4 percent) had concomitant spondylodiscitis. Primary surgery for infective endocarditis was performed in 76.6 percent of patients, and primary surgery for spondylodiscitis in 23.3 percent of patients. The most common microorganisms detected were enterococci and staphylococcus aureus, followed by streptococci and coagulase-negative staphylococci. If spondylodiscitis was operated on first, 30-day mortality was significantly higher than if infective endocarditis was operated on first (25.7 percent versus 11.4 percent; p = 0.037). Primary surgery for spondylodiscitis was an independent predictor of 30-day mortality on multivariable regression analysis.

Source: Journal of the American Heart Association
Author(s): Mateo Marin‐Cuartas, Suzanne de Waha, Manuela de la Cuesta, Salil V. Deo, Alexander Kaminski, Andreas Fach, Anna L. Meyer, Aron‐Frederik Popov, , Christian Hagl, Dominik Joskowiak, Elmar W. Kuhn, Fabio Ius, Florian Leuschner, George Awad, Holger Thiele, Ali Abdalla, Jens Garbade, Joerg Ender, Katharina Wehrmann, Kaveh Eghbalzadeh, Keti Vitanova, Lenard Conradi, Mahmoud Diab, Marcus Franz, Martin Geyer, Massimiliano Meineri, Martin Misfeld, Mohamed Abdel‐Wahab, Oliver D. Bhadra, Rico Osteresch, Rodrigo Sandoval Boburg, Rüdiger Lange, Sergey Leontyev, Shekhar Saha, Steffen Desch, Sven Lehmann, Thilo Noack, Torsten Doenst, Michael A. Borger, and Philipp Kiefer

The number of patients at intermediate and low surgical risk treated by transcatheter aortic valve implantation (TAVI) is rapidly increasing. Current guidelines recommend performing TAVI in heart valve centers with surgical backup. Nonetheless, there is an ongoing discussion about possibly abrogating on‐site surgical backup for TAVI procedures to increase accessibility. However, concerns and uncertainty exist about the safety of performing TAVI in nonsurgical centers.

This collaborative effort, using pooled data from 14 German centers, presents contemporary outcomes of patients undergoing emergency open-heart surgery (E-OHS) due to severe intraprocedural complications during elective transfemoral TAVI. 

The authors conclude that in the setting of a heart team approach with immediate surgical backup, E‐OHS due to potentially lethal TAVI complications is not a futile clinical situation, with acceptable short‐ and long‐term outcomes, especially in low and intermediate-risk patients.

Source: The Annals of Thoracic Surgery
Author(s): Malak Elbatarny, Santi Trimarchi, Amit Korach, Marco Di Eusanio, Davide Pacini, Raffi Bekeredjian, Truls Myrmel, Joseph E. Bavaria, Nimesh D. Desai, Ibrahim Sultan, Derek R. Brinster, Chih-Wen Pai, Kim A. Eagle, Himanshu J. Patel, Mark D. Peterson

A cohort of 2145 patients from the International Registry of Acute Aortic Dissection were compared according to whether they had axillary (1106 [52 percent]) or femoral (1039 [48 percent]) arterial cannulation. Patients with axillary cannulation had more total arch (15 percent versus 11 percent, P < .02) and valve-sparing root replacements (22 percent versus 12 percent, P < .001), but in-hospital mortality (15 percent versus 14 percent, respectively; P = .7) and stroke rates were similar compared with femoral cannulation.

Source: The Annals of Thoracic Surgery
Author(s): Suk Kyung Lim, Chu Hyun Kim, Ki Hong Choi, Joong Hyun Ahn, Young Keun On, Sung Mok Kim, Dong Seop Jeong

In a single-center series of 502 patients who underwent thoracoscopic ablation and left atrial appendage closure, of whom 333 had preoperative and postoperative computed tomographic imaging, complete left atrial appendage closure (defined as residual stump <1 cm on computed tomography one year postoperatively) was lower with the stapled resection (83 percent) compared with a clip (96 percent), and the residual left atrial appendage stump depth was greater (5.3 vs 2.9 mm, respectively). Two patients with a residual stump experienced an ischemic stroke during follow-up. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Sorush Rokui, Byron Gottschalk, Defen Peng, Rosalind Groenewoud, Jian Ye

In this paper, the authors completed a propensity matched retrospective observational study to compare long-term outcomes of isolated mechanical versus bioprosthetic mitral valves in different age groups. After propensity matching, analysis was completed in two age groups: < 65 and 65–75 years. Ten-year survival and freedom from reintervention were superior in those less than 65 years and receiving mechanical valves. In patients aged between 65–75, there was no difference in survival or freedom from reintervention between valve prosthesis. 

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Kai Chen, Zhenyi Niu, Runsen Jin, Qiang Nie, Xian Gong, Mingyuan Du, Benyuan Jiang, Bin Zheng, Chun Chen, Wenzhao Zhong, Hecheng Li

The authors report the results of their randomized controlled trial (RCT) exploring the use of preoperative CT three-dimensional (3D) reconstruction and its impact on operative time and outcomes in thoracoscopic segmentectomy. The authors conducted a multicenter (three hospitals) RCT between 2019 and 2023, randomizing patients 1:1 to either 3D reconstruction CT or standard chest CT. The primary endpoint was operative time. Overall, 191 patients with small peripheral tumors were randomized. There was no statistically significant difference in operative time or clinical outcomes between the groups.

Source: The Annals of Thoracic Surgery
Author(s): Sadia Tasnim, Siva Raja, Eugene H. Blackstone, Andrew J. Toth, John O. Barron, Daniel P. Raymond, Alejandro C. Bribriesco, Dean P. Schraufnagel, Sudish C. Murthy, Monisha Sudarshan

Of 1,579 patients undergoing esophagectomy for esophageal cancer, 60 patients underwent up-front surgery for cT2 N0 M0 esophageal cancer, of whom 8 (13 percent) were found to have pathologic T2 N0 M0, 16 (27 percent) were pathologically downstaged, and 36 (60 percent) were upstaged, 7 (19 percent) on the basis of pathologic T stage, 14 (39 percent) on pathologic N stage, and 15 (42 percent) had upstaging of T and N stages. Dysphagia and high maximum standardized uptake value of the tumor were predictive of more advanced underlying disease.

Source: European Heart Journal
Author(s): Johannes Holfeld, Felix Nägele, Leo Pölzl, Clemens Engler, Michael Graber, Jakob Hirsch, Sophia Schmidt, Agnes Mayr, Felix Troger, Mathias Pamminger, Markus Theurl, Michael Schreinlechner, Nikolay Sappler, Elfriede Ruttmann-Ulmer, Wolfgang Schaden, John P Cooke, Hanno Ulmer, Axel Bauer, Can Gollmann-Tepeköylü, Michael Grimm

This study evaluated the outcomes after the use of cardiac shockwave therapy (SWT) combined with coronary artery bypass surgery (CABG) in patients with reduced left ventricular ejection fraction (LVEF) due to ischemic cardiomyopathy. Patients with LVEF ≤ 40 percent requiring CABG were enrolled in this single-blind, parallel-group, sham-controlled trial. Patients were randomly assigned to undergo direct cardiac SWT or sham treatment in addition to CABG. The primary efficacy endpoint was the improvement in LVEF measured by cardiac magnetic resonance imaging from baseline to 360 days. A total of 63 patients were randomized, 30 patients in the SWT group and 28 patients in the sham group. A greater improvement in LVEF was observed in the SWT group (Δ from baseline to 360 days: SWT 11.3 percent; Sham 6.3 percent, SD 7.4, P = 0.0146). Furthermore, patients in the SWT group significantly improved in the six minute walking test 360 days after randomization. The authors conclude that direct cardiac SWT, in addition to CABG, improves LVEF and physical capacity in patients with ischemic heart failure.

Source: Society for Cardiothoracic Surgery in Great Britain and Ireland
Author(s): Aang Oo

This video is a balanced, gripping presentation on an increasingly common emergency problem for the on-call cardiac surgeon. Professor Oo discusses the evolving landscape of surgery for acute De Bakey I and II pathologies of the aortic organ. He discusses device use for malperfusion and juxtaposes it with FET and more simple, traditional options to treat acute type A aortic dissections.

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