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Journal and News Scan
This study compared the effects and complications of prone positioning (PP) in obese vs non-obese patients with moderate-to-severe acute respiratory distress syndrome after cardiothoracic surgery. A retrospective analysis was conducted using a database established between 2014 and 2021 in an intensive care unit, with the primary endpoint being the change in PaO2/FiO2 induced by PP in groups with and without obesity (body mass index >30 kg/m2). A total of 81 patients with acute respiratory distress syndrome (36 with vs 45 without obesity) and 189 PP sessions were included. This study found that the improvement of oxygenation was not statistically different between patients with and without obesity. However, pressure ulcers were more common in the obese group, whereas mediastinitis was not significantly different between the groups.
This study aimed to compare the clinical and echocardiographic long-term results of edge-to-edge (E-to-E) repair and neochordal repair, both associated with ring annuloplasty, for isolated anterior mitral leaflet lesions using propensity match analysis. A retrospective review of an institutional database from 2000 to 2021 was conducted using the Kaplan–Meier method and cumulative incidence function. Cox regression was used to identify risk factors for mortality during follow-up. The estimated freedom from reoperative mitral valve surgery at 20 years was 78 percent in the E-to-E group and 64 percent in the neochordal group. Additionally, longitudinal analysis of the mitral regurgitation recurrence rate showed a higher rate of recurrence in the neochordal group at 5, 10, and 15 years.
The VRECOVERY trial investigated the impact of virtual reality (VR) distraction therapy on postoperative pain, anxiety, and quality of recovery in patients undergoing coronary artery bypass grafting (CABG) surgery as a single-center randomized controlled trial. A total of 192 participants were allocated to either the intervention or control group. The intervention group received VR distraction therapy on postoperative days 1, 2 and 3, while the control group received standard postoperative care. Primary outcomes were measured in both groups directly following the VR sessions in the intervention group. Of the initial participants, 100 patients completed the trial, and it was noted that VR-distraction therapy demonstrated a significant decrease in postoperative pain and anxiety levels compared to the control group.
This study investigates the impact of tumor spread through air spaces (STAS) on surgical outcomes for early-stage non-small cell lung cancer (NSCLC). In a retrospective analysis of 785 patients, 19.2 percent were found to have STAS-positive NSCLC. The study revealed no significant difference in overall survival (OS) or recurrence-free survival (RFS) between segmentectomy and lobectomy for STAS-negative patients. However, for STAS-positive patients, segmentectomy was associated with significantly worse outcomes, with a three-year OS of 58.4 percent compared to 89.0 percent for lobectomy (p < 0.001), and a three-year RFS of 69.8 percent vs. 82.7 percent (p < 0.001).
This study is crucial for the cardiothoracic surgery community as it reinforces the need for careful surgical planning in STAS-positive NSCLC cases. It highlights the importance of considering STAS status when choosing between segmentectomy and lobectomy to optimize oncological outcomes.
This study investigated the impact of nighttime intensive staffing and failure to rescue (FTR) after cardiac surgery. This study compared two eras that were characterized by the presence and absence of nighttime intensivists staffing. The results showed that nighttime ICU coverage reduced FTR rates in postcardiotomy patients while complication rates and ICU census remained stable. Furthermore, the increase in relative value units suggested an economically stable model.
This study compared teenaged and adult patients with Down syndrome (DS) who underwent cardiac surgery with those without DS. Patients with DS had longer hospital stays, more mechanical ventilation, higher rates of postoperative complications, and greater need for respiratory support, but no increased mortality. Risk factors for extended hospital stays included pulmonary medication use, immunodeficiency, and moderate or greater tricuspid regurgitation. Despite these challenges, cardiac surgery can be safely performed in older DS patients with careful management of these risk factors.
The debate continues over long-term outcomes of percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease. This study, based on the SWEDEHEART registry, analyzed 57,097 revascularized patients with NSTEMI and multivessel disease in Sweden from January 2005 to June 2022. The primary endpoint was all-cause mortality, encompassing both in-hospital and long-term mortality.
Percutaneous coronary intervention was the primary therapy in 42,190 patients (73.9 percent), while 14,907 (26.1 percent) received CABG. During a median follow-up of 7.1 years, PCI was associated with higher risks of death (adjusted odds ratio [aOR] 1.67; 95 percent confidence interval [CI] 1.54-1.81) and MI (aOR 1.51; 95 percent CI 1.41-1.62), but there was no significant difference in stroke. Repeat revascularization was three times more likely to PCI (aOR 3.01; 95 percent CI 2.57-3.51), while heart failure risk was 15 percent higher (aOR 1.15; 95% CI 1.07-1.25). CABG provided longer survival within 15 years, especially in patients under 70 years of age, with left main disease or left ventricular dysfunction, though, this benefit diminished over shorter time horizons.
The authors concluded that CABG is associated with lower risks of mortality, MI, repeat revascularization, and heart failure in patients with NSTEMI, particularly in high-risk subgroups. However, its survival benefit lessens with shorter life expectancy.
Lung cancer remains the leading cause of cancer-related deaths, and low-dose computed tomography screening can reduce mortality for high-risk individuals. In 2021, the US Preventive Services Task Force (USPSTF) expanded lung cancer screening (LCS) guidelines to include adults aged 50 to 79 with a history of 20 or more years of smoking, who are current or recent (within 15 years) smokers. This study analyzed data from the 2022 Behavioral Risk Factor Surveillance System to investigate the prevalence of LCS based on eligibility according to USPSTF criteria. This study found that nearly half of LCS was outside USPSTF recommendations, and ineligible individuals often sought screening despite not meeting the criteria. This raises concerns about the reasons for seeking screening among those not considered high risk. Further research is needed to understand the benefits and risks of screening outside of USPSTF guidelines.
This study analyzed mechanisms of repair failure after mitral valve repair using chordal replacement and annuloplasty for degenerative mitral regurgitation. Between 2003 and 2010, 344 patients underwent mitral valve repair at the German Heart Center Munich. After a mean follow-up of 9.7 years, 38 patients (11 percent) required reoperation, with causes of failure being disease progression (39.5 percent), technical failure (38.8 percent), and endocarditis (18.4 percent). Re-repair was performed in 28.9 percent of cases, often involving redo annuloplasty or chordal replacement. Mitral valve replacement was needed in 63.2 percent of cases, particularly in patients with mitral valve sclerosis. Redo mitral valve repair was more common for technical failure, while mitral valve replacement was more often needed for valve sclerosis.
This article presents findings from the second-ever pig-to-human heart xenotransplant. A 58-year-old patient with end-stage heart failure received a 10-gene-edited porcine heart and was maintained on a novel anti-CD40L immunosuppressive regimen. Initially, the graft functioned well, but by day 31, the patient developed severe diastolic heart failure and required ECMO. The xenograft ultimately failed due to endothelial injury and antibody-mediated rejection (AMR), despite aggressive immunosuppression. No evidence of porcine cytomegalovirus was found, ruling out infection as a contributing factor.
This study is crucial for cardiothoracic surgery, highlighting both the progress and ongoing challenges in xenotransplantation. These findings provide insights into improving immunosuppressive strategies, refining donor selection, and overcoming rejection, bringing xenotransplantation closer to clinical viability as an alternative to human heart transplantation.