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Coronary artery disease severity and aortic stenosis: clinical outcomes according to SYNTAX score in patients undergoing transcatheter aortic valve implantation

Wednesday, April 9, 2014

Submitted by

J. Rafael Sadaba

Source

Source Name: European Heart Journal

Source URL: http://www.ncbi.nlm.nih.gov/pubmed/24682843

Author(s)

Stefanini GG, Stortecky S, Cao D, Rat-Wirtzler J, O'Sullivan CJ, Gloekler S, Buellesfeld L, Khattab AA, Nietlispach F, Pilgrim T, Huber C, Carrel T, Meier B, Jüni P, Wenaweser P, Windecker S.

In this study the authors looked at the impact of coronary artery disease (CAD) in a single series of 445 patients undergoing TAVI for aortic valve stenosis. The pre-established primary endpoint of the study was a composite of cardiovascular death, stroke, or myocardial infarction (MI)—at 1 year. Patients were divided into three groups according to the severity of CAD as determined by the SYNTAX score (SS): no CAD, CAD with SS ≤ 22 and CAD with SS >22. At 1-year, increased CAD severity was associated with higher rates of the primary endpoint. This was mainly driven by a difference in cardiovascular death. The risk of stroke and MI was similar in all three groups.