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Impact of Preoperative Chronic Kidney Disease in 2,531 High-Risk and Inoperable Patients Undergoing Transcatheter Aortic Valve Replacement in the PARTNER Trial

Tuesday, September 27, 2016

Submitted by

Mark Ferguson

Source

Source Name: Annals of Thoracic Surgery

Source URL: http://www.annalsthoracicsurgery.org/article/S0003-4975(16)30870-0/abstract

Author(s)

Vinod H Thourani, Jessica Forcillo, Nirat Beohar, Darshan Doshi, Rupa Parvataneni, Girma M Ayele, Ajay J Kirtane, Vasilis Babaliaros, Susheel K Kodali, Chandan Devireddy, Wilson Y Szeto, Howard C Herrmann, Raj Makkar, Gorav Ailawadi, Scott Lim, Hersh S. Maniar, Alan Zajarias, Rakesh M Suri, E. Murat Tuzcu, Samir Kapadia, Lars G. Svensson, Jose Condado, Hanna A Jensen, Michael J Mack, and Martin B Leon

This analysis of PARTNER data evaluated the impact of chronic kidney disease (CKD) on outcomes after TAVR. Patients were grouped according to GFR as none/mild, moderate, and severe renal disease. Severe disease was most common among women with diabetes. Severe disease was associated with a 50% increase in 30-day mortality and 1-year cominbed mortality and all-cause rehospitalization. Assessment of renal function may help risk stratify patients who are candidates for TAVR.