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Journal and News Scan
The 5-year outcomes of a Veterans Affairs trial of off-pump vs on-pump CABG are reported. Mortality in the off-pump group was 15.2% compared to 11.9% in the on-pump group (RR 1.28; p=0.02). Composite adverse events were more common in the off-pump group (31.0% vs 27.1%; RR 1.14; p=0.046). Repeat CABG was more common for the off-pump group (1.4% vs 0.5%; p=0.02). No differences were observed in nonfatal MI, death from cardiac causes, or repeat revascularization.
The Yale group retrospectively reviewed their experience with DeBakey type I aortic dissections to evaluate whether patients with bovine aortic arches had a unique distribution of entry sites and differential outcomes. A total of 315 patients were included in the study, of which 49 (16%) had a bovine aortic arch. The authors found that those patients with bovine aortic arches were 6 times more likely to have arch tears and 2.7 times more likely to suffer a stroke as those without bovine aortic arches.
The Cleveland Clinic group performed a randomized clinical trial comparing transfusion triggers of 24% vs. 28% from 2007-2014. The study included 722 patients who underwent either CABG or valve surgery. While the lower trigger group received fewer transfusions, adverse outcomes did not differ between the groups. Because the lower trigger group had equivalent outcomes but fewer transfusions, the authors recommend using a lower trigger perioperatively.
In an era of VATS surgery this is a very interesting article documenting advanced in thoracotomy and open chest surgery.
It shows us that open surgeons are also significantly improving their techniques, and the very large postero-lateral thoracotomy with rib cutting and costo-transverse ligament division may in most cases be replaced by muscle sparing and smaller incision techniques while still allowing a full open operation.
This is a very courageous and interesting article, and we should all acknowledge that modern thoracotomy is very different from the thoracotomies of the past.
Well done Dr Navarro.
Patient Care
A heart team at Kingston Health Sciences Centre in Ontario performs the first hybrid cardiac ablation for atrial fibrillation in Canada.
A five-year-old boy from Newcastle, South Africa, is among the youngest and smallest people to receive a heart ventricular assist device.
Surgical teams in Armenia already use minimally invasive procedures in the abdominal cavity, and they will soon add them to their arsenal of tools for treating lung cancer.
A cardiac surgery resident in Edmonton, Canada, has designed paper toys that help teach pediatric patients about their hearts and hospital stays.
News outlets highlight athletic successes of transplant patients including a cyclist from Fairlie, United Kingdom, and a swimmer from Michigan, USA, who medaled in the World Transplant Games in Málaga, Spain.
Two paramedics in New York, USA, responded immediately when a nurse suffered a cardiac arrest in their home during a postsurgical follow-up visit.
Drugs and Devices
Surgeons have implanted the first Biostage Cellspan esophageal implant, in which a patient’s stem cells are seeded onto an esophageal scaffold.
Research, Trials, and Funding
Physicians from the Cleveland Clinic in Ohio wrote a letter to the New England Journal of Medicine where they report a decrease in nitroprusside and isoproterenol usage at 47 US hospitals following price hikes in the cost of each drug.
A highly-detailed, 3D representation of the cardiac conduction system in the intact human heart is published in Scientific Reports.
The University of Maryland School of Medicine has received a grant to establish the first cardiac xenotransplantation research center in the USA.
This prospective study evaluated whether intraoperative molecular imaging (IMI) with a folate receptor targeted contrast agent visible in the near-infrared spectrum improved the detection of peripheral malignant lung nodules. Fifty patients undergoing surgery for peripheral nodules had a preoperative PET scan and were imaged intraoperatively. IMI identified 95% of nodules and 9 additional lesions not seen preoperatively. IMI sensitivity was greater than that of PET (96% vs 74%) and had a greater positive predictive value (94% vs 89%). IMI improved management in 30% of patients.
Hraska and colleagues present a retrospective study of outcomes following congenitally corrected transposition of the great arteries using the morphologically left ventricle as the systemic pumping chamber. Patients were followed for a median of 5 years, with a range up to 20 years. Overall survival and event-free survival were good, and only one of the 63 patients had worse than mild dysfunction of the morphologically left ventricle.
This research was presented at the 2017 Annual Meeting of The Society of Thoracic Surgeons, and the audio discussion that followed the presentation accompanies the article.
Despite VATS lobectomy being 25 years old, we do need definitive results urgently and from large randomised clinical trials in order to demonstrate the remarkable advantage for the patients undergoing major lung resection by minimally invasive approach. Looking forward to seeing the results of this French multicentric trial and from the ongoing VIOLET trial from UK.
Ghoneim and colleagues retrospectively evaluated surgical risk caused by prior mediastinal radiation therapy (MRT) in patients undergoing aortic valve replacement (AVR). The authors found that operative mortality was higher than predicted when AVR was performed with concomitant procedures, and they speculate this is in part related to the longer cardiopulmonary bypass time required. Despite good short-term outcomes in the isolated AVR group, MRT patients undergoing both isolated and concomitant AVR had reduced midterm survival. The authors suggest this should be considered when weighing the choice of device, the invasiveness of the AVR procedure, and the inclusion of concomitant procedures for this population of patients.
Patient Care
An Iraqi boy from Mosul went from Jordan to Australia for surgery to correct the blood flow through his heart and repair a hole between his ventricles.
Transcatheter approaches continue growing as transcatheter aortic valve implantation (TAVI) is performed for the first time in Kenya at the Aga Khan University Hospital and in Bangladesh at the United Hospital Ltd.
The Palestinian Authority chief negotiator will need a lung transplant as medical treatment for his pulmonary fibrosis is no longer sufficient.
A professional basketball player in the USA talks about undergoing and recovering from open heart surgery.
Drugs and Devices
Mayo Clinic in Rochester, Minnesota, is partnering with AliveCor to improve early detection of long QT syndrome with AliveCor’s Kardia Mobile device.
The European Medicines Agency must relocate from its current London offices ahead of Brexit (the UK leaving the European Union), and 19 different cities are vying to be the agency’s new home.
The Avalus pericardial aortic surgical valve from Medtronic, an MRI-safe stented valve, is now CE (Conformité Européenne) marked and has received US Food and Drug Administration approval. Medtronic also announced CE mark and the European launch of the CoreValveTM EvolutTM PRO valve.
Research, Trials, and Funding
Researchers at Ohio State University in Columbus, Ohio, find that the human heart has multiple pacing mechanisms with redundancies in the sinoatrial node.
Researchers at the CSIR Institute of Genomics and Integrative Biology in New Delhi, India, will soon start a longitudinal study of the factors affecting lung function in children.