A useful if somewhat belated account of the Papworth experience in lung donation after circulatory determined death (DCD) until 2015. There are no data on heart and lung transplants in that 6-year period. No DCD recipient required extracorporeal membrane oxygenation, and DCD single lung recipients did badly.
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Critical Care
August 10, 2018
The latest instalment in the gender discordance saga, this one proferred by business/management school academics. I am not convinced that the coarse gender comparison takes into account the size discrepancy in coronary arteries and other, well-known to medical practitioners, anatomico-physiological differences of human genders.
August 9, 2018
This study shows the use of inhaled nitric oxide (NO) via noninvasive means (nasal prongs or high flow nasal cannulae) is an effective method for reduction of PV resistance. With right ventricular dysfunction becoming an increasingly recognised event after cardiac surgery, this allows for application of NO without the need for intubation.
August 9, 2018
This is a further report from the extensive dataset of the STICH Trial. This examines the impact of immediate postoperative events (length of time of intubation) on short- and long-term outcomes. If the time was >36 hours, there was significant correlation with increased mortality, both 30-day and one-year.
July 26, 2018
Barili and colleagues discuss the importance of identifying heterogeneity in meta-analyses and the use of a random-effects or fixed-effects model to account for differences between or within studies. The authors review the assumptions and components of these models, discussing appropriate applications for each of them.
July 11, 2018
Papageorgiou and colleagues discuss dealing with missing data, a common challenge in clinical research.
June 28, 2018
Chan and colleagues describe a stepwise approach to reducing the time to extubation after cardiac surgery, driven primarily by bedside providers as opposed to a conventional physician-directed approach.
June 27, 2018
A brief, readable, sensibly balanced, and well-referenced editorial on the occasion of the retrospective Austrian paper on venoarterial extracorporeal membrane oxygenation (ECMO).
June 26, 2018
Sample size calculations are a necessary prerequisite in the design of clinical studies. Most often, they are encountered in randomized controlled trials. Hickey and colleagues describe the reasoning behind determinations of sample size and illustrate some basic calculations.
June 21, 2018
Marco Ranucci of the IRCCS Policlinico San Donato in Italy discusses the association between hemodilution, oxygen delivery, and acute kidney injury.