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Heart Failure - Congestive

Does Small Size Matter With Continuous Flow Devices? : Analysis of the INTERMACS Database of Adults With BSA ≤1.5 m2
February 15, 2017
The authors reviewed the retrospective INTERMACS database to assess whether outcomes after continuous-flow (CF) LVAD implantation varied with patient BSA.  A total of over 10,000 CF LVAD patients were included.  Of these, 231 (2%) had a BSA < 1.5 m².  
Cost-Effectiveness of Left Ventricular Assist Devices in Ambulatory Patients With Advanced Heart Failure
January 13, 2017
With the everpresent question of potentially extending LVAD therapy to ambulatory patients with advanced heart failure, the authors--using a Markov model--projected the incremental cost-efffectiveness ratio (ICER) of DT LVADs in this population as compared to conventional medical therapy.
Contemporary extracorporeal membrane oxygenation therapy in adults: Fundamental principles and systematic review of the evidence.
July 18, 2016
A handy mini-textbook on ECMO
Donor Troponin and Survival After Cardiac Transplantation. An Analysis of the United Network of Organ Sharing Registry
June 25, 2016
A large retrospective study of the UNOS database advances that elevated troponin I  in selected cardiac donors is NOT associated with various adverse events. The conclusion is likely to stimulate heated discussions.
Cardiac resynchronization therapy combined with coronary artery bypass grafting in ischaemic heart failure patients: long-term results of the RESCUE study
January 9, 2016
The authors performed a randomized control study of 178 patients with heart failure and systolic dyssynchrony who were accepted for CABG, randomizing the participants into two groups:  CABG alone (n=87) and CABG + concomitant epicardial CRT (n=91).  CRT was activated postoperatively.
Human Ventricular Unloading Induces Cardiomyocyte Proliferation
January 25, 2015
This study from the University of Texas Southwestern sought to analyze the effects of mechanical unloading during prolonged LVAD support on mitochondrial mass, DNA damage response (DDR), and cardiomyocyte proliferation.  Ten matched human samples of LV myocardium were analyzed before and after mechanical circulatory support.
Bridge to Removal: A Paradigm Shift for Left Ventricular Assist Device Therapy
November 15, 2014
Selzman and colleagues provide an outstanding overview of the state of the art of bridge to recovery, describing a paradigm shift that has been occurring.  A consistent theme over the years is that recovery likelihood is enhanced in younger patients, those with non-ischemic cardiomyopathy, and those who have had HF for shorter durations.
Effect of Exercise and Pump Speed Modulation on Invasive Hemodynamics in Patients with Centrifugal Continuous Flow Left Ventricular Assist Devices
November 10, 2014
The effects of exercise, increasing pump speed, or both on invasive hemodynamics in centrifugal flow LVAD patients were analyzed in this small study.  Findings included:

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