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3-Year Outcomes in High-Risk Patients Who Underwent Surgical or Transcatheter Aortic Valve Replacement

Saturday, June 11, 2016

Submitted by

J. Rafael Sadaba

Source

Source Name: Journal of the American College of Cardiology

Source URL: http://content.onlinejacc.org/article.aspx?articleID=2506791

Author(s)

Deeb GM, Reardon MJ, Chetcuti S, Patel HJ, Grossman PM, Yakubov SJ, Kleiman NS, Coselli JS, Gleason TG, Lee JS, Hermiller JB Jr, Heiser J, Merhi W, Zorn GL 3rd, Tadros P, Robinson N, Petrossian G, Hughes GC, Harrison JK, Maini B, Mumtaz M, Conte J, Resar J, Aharonian V, Pfeffer T, Oh JK, Qiao H, Adams DH, Popma JJ; CoreValve US Clinical Investigators.

This manuscript reports on the 3-year follow up results of the CoreValve US Pivotal Trial in which patients with aortic stenosis at high risk for surgery were randomly assigned to self-expanding TAVR or SAVR in a 1:1 manner. At 3 years, the results of this analysis demonstrate a sustained 3-year clinical benefit of TAVR with a self-expanding prosthesis over SAVR. There was a reduction in all-cause mortality and stroke. TAVR was also shown to have lower 3-year mean aortic valve gradients and larger effective orifice areas compared with SAVR. Moderate or severe AR was higher with TAVR compared with SAVR. There were no differences in the occurrence of structural valve deterioration over time in the 2 groups.