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CABG-related bleeding complications in real-life acute coronary syndrome patients treated with clopidogrel or ticagrelor

Thursday, October 9, 2014

Submitted by

Joel Dunning

Source

Source Name: European Journal of Cardio-Thoracic Surgery

Source URL: http://ejcts.oxfordjournals.org/content/46/4/699.abstract

Author(s)

Emma C. Hansson, Helena Rexius, Mikael Dellborg, Per Albertsson, and Anders Jeppsson

This prospective observational study compares patients with coronary artery bypass grafting on aspirin and ticagrelor (n = 173) or on aspirin and clopidogrel (n = 232). Major bleeding complications occurred in 14.5% with ticagrelor and 13.8% with clopidogrel (p=0.89).

No significant differences were observed, too, when the drugs were discontinued ≥5 or 2-4 days before surgery. A strong tendency to more bleeding complications in the ticagrelor group was found, however, when the drugs were given until 0–1 day before surgery.