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Cardiac-Resynchronization Therapy in Heart Failure with a Narrow QRS Complex

Thursday, October 10, 2013

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Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1306687

Author(s)

Frank Ruschitzka, William T. Abraham, Jagmeet P. Singh, Jeroen J. Bax, Jeffrey S. Borer, Josep Brugada, Kenneth Dickstein, Ian Ford, John Gorcsan, III, Daniel Gras, Henry Krum, Peter Sogaard, and Johannes Holzmeister for the EchoCRT Study Group

This randomized trial among 115 centers assigned patients with NYHA class III or IV heart failure, a short QRS duration, and LV dyssynchrony to device implantation with or without CRT. The study was stopped prematurely by the DSMB for futility. CRT was associated with increased deaths (p=0.02) and there was no difference in the primary outcome of death or hospitalization for worsening heart failure.