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Edoxaban versus Warfarin in Patients with Atrial Fibrillation

Wednesday, November 27, 2013

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Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1310907?query=featured_home

Author(s)

RP Giugliano and others for ENGAGE AF-TIMI 48 Investigators

The efficacy of high dose and low dose Edoxaban, an oral factor Xa inhibitor, was compared to Warfarin in patients with high risk a-fib. The efficacy endpoint was stroke or systemic embolus, the safety endpoint was bleeding. Edoxaban was non-inferior to Warfarin for both doses in terms of efficacy, and was associated with reduced risks of bleeding and cardiovascular death.