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Five-Year Outcomes With PCI Guided by Fractional Flow Reserve

Wednesday, May 23, 2018

Submitted by

Mark Ferguson

Source

Source Name: The New England Journal of Medicine

Source URL: https://www.nejm.org/doi/full/10.1056/NEJMoa1803538

Author(s)

Panagiotis Xaplanteris, Stephane Fournier, Nico H.J. Pijls, William F. Fearon, Emanuele Barbato, Pim A.L. Tonino, Thomas Engstrøm, Stefan Kääb, Jan-Henk Dambrink, Gilles Rioufol, Gabor G. Toth, Zsolt Piroth, Nils Witt, Ole Fröbert, Petr Kala, Axel Linke, Nicola Jagic, Martin Mates, Kreton Mavromatis, Habib Samady, Anand Irimpen, Keith Oldroyd, Gianluca Campo, Martina Rothenbühler, Peter Jüni, Bernard De Bruyne, for the FAME 2 Investigators

Over 1200 patients with stable coronary artery disease and at least one angiographically-significant stenosis were randomized to percutaneous coronary intervention (PCI) plus medical therapy or medical therapy alone for lesions with fractional flow reserve (FFR) <0.8. FFR-guided PCI was associated with a significantly reduced composite outcome (death, myocardial infarction, or urgent revascularization). Patients without hemodynamically significant lesions had good outcomes on medical therapy alone.