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Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes

Tuesday, January 12, 2016

Submitted by

Ruben Osnabrugge

Source

Source Name: Circulation

Source URL: http://www.ncbi.nlm.nih.gov/pubmed/26647082

Author(s)

Harskamp RE, Alexander JH, Ferguson TB Jr, Hager R, Mack MJ, Englum B, Wojdyla D, Schulte PJ, Kouchoukos NT, de Winter RJ, Gibson CM, Peterson ED, Harrington RA, Smith PK, Lopes RD.

The authors of this paper aimed to study the frequency and predictors of internal mammary artery (IMA) failure in 1539 patients who underwent IMA revascularization of the left anterior descending (LAD) artery. IMA failure was defined as >75% stenosis at a follow-up of 12-18 months. They found that IMA failure occured in 8.6%. IMA failure was associated with LAD stenosis <75% (odds ratio 1.76), not having diabetes mellitus (OR 1.82) and an additional bypass graft to the diagonal branch (OR 1.92). IMA failure was associated with higher rates of acute clinical events after follow-up angiography. The investigators conclude that these findings suggest that the benefit of CABG in moderate LAD stenosis without functional ischemia could be matter of debate.