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High versus Low Blood-Pressure Target in Patients with Septic Shock

Tuesday, March 18, 2014

Submitted by

Mark Ferguson

Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1312173?query=OF

Author(s)

P Asfar and others for the SEPSISPAM Investigators

This randomized trial assigned septic pts to resuscitation with a MAP goal of 80-85 mm Hg or 65-70 mm Hg. There was no difference in mortality at 30 or 90 days. Afib was more common in the high goal pts, and high goal pts with chronic hypertension required less renal replacement therapy.