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Importance of Surveillance and Success of Salvage Strategies After Definitive Chemoradiation in Patients With Esophageal Cancer

Tuesday, September 16, 2014

Submitted by

Mark Ferguson

Source

Source Name: Journal of Clinical Oncology

Source URL: http://jco.ascopubs.org/content/early/2014/09/15/JCO.2014.56.7156?cmpid=jco_pap_…

Author(s)

Kazuki Sudo, Lianchun Xiao, Roopma Wadhwa, Hironori Shiozaki, Elena Elimova, Takashi Taketa, Mariela A. Blum, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, William A. Ross, Ritsuko Komaki, David C. Rice, Stephen G. Swisher, Wayne L. Hofstetter, Dipen M. Maru, Heath D. Skinner and Jaffer A. Ajani

This retrospective study evaluated recurrence patterns and management of recurrence after bimodality (chemoradiotherapy) for esophageal cancer in 276 pts. Local relapse alone developed in 23%, and 36% of those patients had salvage esophagectomy. Median survival for those undergoing salvage esophagectomy was 59 mos, whereas pts who were not offered salvage esophagectomy had a median survival of 9.5 mos. Over 90% of isolated relapses occured during the first 2 years.