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Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery

Thursday, September 17, 2015

Submitted by

CTSNet Staff

Source

Source Name: Eur J Cardiothorac Surg

Source URL: http://ejcts.oxfordjournals.org/content/48/3/354.abstract

Author(s)

Eshan L. Senanayake, Neil J. Howell, Aaron M. Ranasinghe, Nigel E. Drury, Nick Freemantle, Michael Frenneaux, Tessa Oelofse, David Green, Ian C. Wilson, Stephen J. Rooney, Jorge Mascaro, Timothy R. Graham, Sunil Bhudia, Michael Lewis, and Domenico Pagano

Perhexilene modulates cardiac metabolism and is expected to provide myocardial protection during cardiac surgery in patients with left ventricular hypertrophy. The agent was tested in a randomized clinical trial and administered per os preoperatively. The primary endpoint was use of inotropics for low cardiac output. The trial was halted after analysis of 110 of 220 planned patients due to the lack of difference between the groups for the primary and also for secondary endpoints.