One-Year Follow-up of Intracoronary Stem Cell Delivery on Left Ventricular Function Following ST-Elevation Myocardial Infarction

This paper reports on the 1-year follow up of the Timing In Myocardial Infarction Evaluation (TIME) trial, in which patients with moderate to large anterior ST elevation myocardial infarction received treatment with intracoronary delivery of 150 million autologous bone marrow mononuclear cells 3 or 7 days following the event. At 1-year, there continued to be no evidence of improvement in the primary end-points of LVEF and regional (infarct and border zone) LV function in the treatment groups compared with the control group, irrespective of cell delivery at 3 or 7 days.