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Patient-Prosthesis Mismatch After Surgical Aortic Valve Replacement: Analysis of the PARTNER Trials

Wednesday, June 5, 2024

Submitted by

Jo Chikwe

Source

Source Name: The Annals of Thoracic Surgery

Source URL: https://www.annalsthoracicsurgery.org/article/S0003-4975(24)00079-1/abstract

Author(s)

Vinod H. Thourani, Amr E. Abbas, Julien Ternacle, Rebecca T. Hahn, Raj Makkar, Susheel K. Kodali, Isaac George, Samir Kapadia, Lars G. Svensson, Wilson Y. Szeto, Howard C. Herrmann, Gorav Ailawadi, Jonathon Leipsic, Philipp Blanke, John Webb, Wael A. Jaber, Mark Russo, S. Chris Malaisrie, Pradeep Yadav, Marie-Annick Clavel, Omar K. Khalique, Neil J. Weissman, Pamela Douglas, Jeroen Bax, Abdellaziz Dahou, Ke Xu, Vinayak Bapat, Maria C. Alu, Martin B. Leon, Michael J. Mack, Philippe Pibarot

In an analysis of 1,826 patients randomized to surgical aortic valve replacement in the three Placement of Aortic Transcatheter Valves (PARTNER) trials, patient-prosthesis mismatch was assessed using transthoracic echocardiography and by the normal reference value for each size and model of implanted valve. Compared with transthoracic echocardiography (21.6 percent), reference values underestimated the incidence of severe patient-prosthesis mismatch (2.1 percent), which was associated with worse all-cause mortality and heart failure rehospitalizations at the two year follow-up.