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Prevention of Atrial Fibrillation in High-risk Patients Undergoing Lung Cancer Surgery: The PRESAGE Trial

Tuesday, August 2, 2016

Submitted by

Mark Ferguson

Source

Source Name: Annals of Surgery

Source URL: http://journals.lww.com/annalsofsurgery/Abstract/2016/08000/Prevention_of_Atrial…

Author(s)

Cardinale, Daniela; Sandri, Maria T; Colombo, Alessandro; Salvatici, Michela; Tedeschi, Ines; Bacchiani, Giulia; Beggiato, Marta; Meroni, Carlo A; Civelli, Maurizio; Lamantia, Giuseppina; Colombo, Nicola; Veglia, Fabrizio; Casiraghi, Monica; Spaggiari, Lorenzo; Venturino, Marco; Cipolla, Carlo M

This randomized trial evaluated the efficacy of postoperative metoprolol or losartan in preventing atrial fibrillation in patients with elevated N-terminal pro-brain natriuretic peptide who were undergoing lung resection for cancer. Among candidates, 29% (320) of patients had elevated NT-proBNP and were randomized. Both metoprolol and losartan reduced afib incidence compared to controls (6%, 12%, 40%).