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Randomized Trial of Preventive Angioplasty in Myocardial Infarction

Sunday, September 1, 2013

Submitted by

Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1305520?query=OF

Author(s)

David S. Wald, Joan K. Morris, Nicholas J. Wald, Alexander J. Chase, Richard J. Edwards, Liam O. Hughes, Colin Berry, and Keith G. Oldroyd, for the PRAMI Investigators

465 pts with acute STEMI who were undergoing urgent PCI were randomized to additional prophylactic PCI of any vessels with significant stenosis or PCI of the target vessel only. The composite outcome was cardiac death + MI + refractory angina. The trial was stopped early because of a incidence of composite outcome of 21 (9 per 100 pts) in the prophylactic PCI group vs 53 (23 per 100 pts) in the control group (HR of 0.35; p<0.001). Similar benefits were seen for each component of the composite outcome.