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Risk for Valvular Heart Disease After Treatment for Hodgkin Lymphoma

Monday, April 13, 2015

Submitted by

Marcelo Jimenez

Source

Source Name: Journal of the National Cancer Institute

Source URL: http://jnci.oxfordjournals.org/content/107/4/djv008.abstract?etoc

Author(s)

David J. Cutter, Michael Schaapveld, Sarah C. Darby, Michael Hauptmann, Frederika A. van Nimwegen, Augustinus D. G. Krol, Cecile P. M. Janus, Flora E. van Leeuwen and Berthe M. P. Aleman

This retrospective case-control study involving 1852 Hodgkin lymphoma 5-year survivors found that radiation to the heart valves tend to increase the risk for clinically significant valvular heart disease. The rate increased 3.1-fold in patients receiving 31-35 Gy and 11.8-fold in those who received > 40 Gy.