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Staphylococcus Aureus Prevention Strategies in Cardiac Surgery: A Cost-Effectiveness Analysis

Thursday, October 12, 2017

Submitted by

Arie Blitz

Source

Source Name: Annals of Thoracic Surgery

Source URL: http://www.annalsthoracicsurgery.org/article/S0003-4975(17)30914-1/abstract

Author(s)

Jonathan C. Hong, Manoj K. Saraswat, Trevor A. Ellison, J. Trent Magruder, Todd Crawford, Julia M. Gardner, William V. Padula, Glenn J. Whitman

The authors, using a decision analysis model, compared the cost-effectiveness (over one year) of three different strategies for preventing Staphylococcus aureus infections in patients undergoing CABG in the U.S. The three strategies were as follows:

Universal decolonization with mupirocin, chlorhexidine, and vancomycin in all patients undergoing CABG
Targeted decolonization with mupirocin, chlorhexidine, and vancomycin only in patients who are S aureus carriers
No decolonization in any patients

Findings: Universal decolonization is the most cost-effective strategy in >91% of simulations in this model. Annually in the US, universal decolonization is predicted to lead to $102 million in cost savings, while targeted decolonization is predicted to lead to $45 million in cost savings.