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Transcriptomic Architecture of the Adjacent Airway Field Cancerization in Non–Small Cell Lung Cancer

Monday, April 14, 2014

Submitted by

Marcelo Jimenez

Source

Source Name: Journal of The National Cancer Institute

Source URL: http://jnci.oxfordjournals.org/content/106/3/dju004.abstract.html?etoc

Author(s)

Humam Kadara, Junya Fujimoto, Suk-Young Yoo, Yuho Maki, Adam C. Gower, Mohamed Kabbout, Melinda M. Garcia, Chi-Wan Chow, Zuoming Chu, Gabriella Mendoza, Li Shen, Neda Kalhor, Waun Ki Hong, Cesar Moran, Jing Wang, Avrum Spira, Kevin R. Coombes and Ignacio I. Wistuba

In this promising investigation, authors have found changes associated with airway cancerization in large airways in lung cancer patients, while these changes are absent in cancer-free smokers. And in addition, with shorter distance from tumors, airway cancerization expression increases statistically.