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A Trial of Intraoperative Low-Tidal-Volume Ventilation in Abdominal Surgery

Thursday, August 1, 2013

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Source

Source Name: New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1301082?query=TOC

Author(s)

Emmanuel Futier, Jean-Michel Constantin, Catherine Paugam-Burtz, Julien Pascal, Mathilde Eurin, Arthur Neuschwander, Emmanuel Marret, Marc Beaussier, Christophe Gutton, Jean-Yves Lefrant, Bernard Allaouchiche, Daniel Verzilli, Marc Leone, Audrey De Jong, Jean-Etienne Bazin, Bruno Pereira, and Samir Jaber for the IMPROVE Study Group

In this multi-institutional prospective trial, 400 pts at increased risk for pulmonary complications after major abdominal surgery were randomized to standard intraoperative ventilator management and lung-protective management with low tidal volumes and PEEP. A composite of pulmonary and extrapulmonary complications occurred in 27.5% of the control group compared to 10.5% of the treatment group at 7 days. The incidence of respiratory failure was 17% in the control group and 5% in the treatment group. The treatment group length of stay was 2.5 days shorter.