The authors studied survival in patients with multiple lung cancers and their associated genetic mutations. There was 90% discordance in driver mutations beween cancers in individual patients that was associated with favorable survival. The two patients in whom condordance was present suffered recurrent cancer.
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Lung - Cancer
January 13, 2018
January 12, 2018
Patient Care
Office-Based Spirometry: A New Model of Care in Preoperative Assessment for Low-Risk Lung Resections
January 10, 2018
The authors compared low risk patients undergoing office spirometry only (FEV1 of >60%) to those undergoing laboratory spirometry followed by lung resection.
January 10, 2018
Among patients aged 65 and older undergoing lung resection for NSCLC, long-term survival was related to cancer stage and patient age. Lobectomy patients fared better than those undergoing parenchymal-sparing resections or pneumonectomy. VATS approaches provided better long-term survival.
Phase 1 Trial Evaluating Safety of Pulmonary Artery Sealing With Ultrasonic Energy in VATS Lobectomy
January 10, 2018
The authors demonstrate that use of an ultrasonic sealing device is safe for pulmonary artery branches 7 mm or less in diameter. This information could substantially reduce costs for lobectomy related to stapler use.
January 10, 2018
The authors explored the optimal extent of LN resection for T1aN0 carcinoid tumors undergoing lung resection using the National Cancer Data Base. Twenty-five percent of patients had no nodes evaluated. Four percent of patients were upstaged based on node status. Survival was similar comparing lobectomy to sublobar resection.
January 3, 2018
This article from the BBC highlights two different artificial intelligence (AI) diagnostic systems, one that evaluates coronary artery disease (CAD) and another that determines whether a lung nodule is cancerous. The systems are being trialed around the UK, and they show promise for improved accuracy of imaging-based diagnoses.
December 14, 2017
Using propensity score matching, patients with clinical stage I NSCLC who underwent either VATS lobectomy or stereotactic body radiotherapy (SBRT) were compared for long-term outcomes. Among 37 matched pairs, tumor control at 3 years was twice as good for surgery (p=.0038), cancer-specific survival was 15 percentage points better for surgery (p=.05
December 13, 2017
As many will recall, world chess champion Garry Kasparov was defeated by IBM's Deep Blue computer in 1997. Now machine-learning algorithms have bested trained pathologists in differentiating between benign and malignant changes in sentinel lymph nodes in breast cancer patients. We can expect to see increasing involvement of AI in pathology as well
December 13, 2017
Liquid biopsies have long held promise for diagnosis, treatment selection, and surveillance of lung cancer patients. This articles summarizes results of two studies involving highly precise measurement of tumor mutational burden. A burden of 16-fold or greater was associated with improved overall survival with immunotherapy (atezolizumab) compared