Data from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study were used to determine the relationship of a genetic risk score associated with obesity to cancer risk. The risk score was not associated with GERD or smoking. Cancer and Barrett's were strongly associated with increasing BMI. The authors conlude that those with a g
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Esophageal Cancer - Other
November 24, 2014
November 20, 2014
Data from 20 observational studies including nearly 3000 pts were reviewed to assess the prevalence of pre-frailty/frailty and clinical outcomes in older cancer patients. Frailty was identified in 42% and pre-frailty in 43% of patients. Combined frailty was associated with increased all cause mortality (5-yr HR 1.57), postoperative mortality, and p
October 8, 2014
The histologic response to induction therapy is usually a binary function. In the current study, the authors explored methods of refining the histologic response classification to improve prediction of prognosis for patients with esophageal adenocarcinoma. They identified 3 unique groups: major response in the primary tumor with ypN0; either major
August 31, 2014
In this retrospective study based on a database of 5390 patients with early-stage esophageal cancer, T1a and T1b lesions were treated by endoscopic (26.5%) or surgical resection (73.5%). For patients undergoing surgery, the incidence of lymph node metastasis was 5.0% for T1a and 16.6% for T1b lesions.
May 29, 2014
This retrospective review included 322 pts undergoing open esophagectomy 2005-2010. Gastric empyting procedures included Botox (78), pyloroplasty (199), and pyloromyotomy (45). Botox was associated with more postop reflux symptoms and required more prokinetic agents.