This randomized trial in New Zealand assigned smokers who wished to quit to either nicotrine replacement therapy or cytisine therapy.
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Lung Cancer - Other
December 10, 2014
This interesting article summarizes the evidence from clinical, radiologic and pathologic investigations that lung cancer, specifically adenocarcinoma, may metastasize through the airways, defined as discontinuous spread of cancer cells from the primary tumor through the airways to adjacent or distant lung parenchyma.
December 6, 2014
A hot topic at the recent meeting of the RSNA (Radiological Society of North America) was the implementation of LungRADS, a scoring system for categorizing lesions on CT, to be utilitized as part of CT screening for lung cancer. Scans are assigned to one of 5 categories, ranging from incomplete to 4A (suspicious, follow-up or further testing warrant
December 3, 2014
This study explored recent patterns of surveillance imaging 4-8 mos after surgical treatment of early stage lung cancer using the SEER database. Initial imaging consisted of CXR (60%), CT (25%) and PET (3%). 13% of patients received no imaging. NCCN guidelines adherence for receipt of CT was 47%, but increased from 28% to 60% over the period of st
November 30, 2014
A reexamination of data from the National Lung Screening Trial (NLST) with nodules above the 4mm, has been shown that increasing the nodule size threshold for a positive screen, substantially reduces the false-positive CT screenings rate and increase slightly the lung cancer missed or delayed but without affecting the survival.
November 24, 2014
Data from the National Lung Screening Trial (NLST) were examined by exploring different size thresholds for classifying CT screening scans as positive. In the NLST, nearly two-thirds of nodules were 7mm in diameter or less. Using a threshold of 5mm, the percentage of missed/delayed diagnosis and the likelihood of avoiding false positive findings we
November 20, 2014
Data from 20 observational studies including nearly 3000 pts were reviewed to assess the prevalence of pre-frailty/frailty and clinical outcomes in older cancer patients. Frailty was identified in 42% and pre-frailty in 43% of patients. Combined frailty was associated with increased all cause mortality (5-yr HR 1.57), postoperative mortality, and p
November 11, 2014
CMS determined that the evidence of benefit for CT screening for lung cancer is sufficient to permit this as an annual benefit for Medicare and Medicaid recipients in the US. The availability of such coverage will be limited, however, by the need to have the screening as part of a comprehensive counseling (smoking cessation, etc) visit with qualifie
November 5, 2014
The authors examined cost-effectiveness in the National Lung Screening Trial (NLST), examining incremental cost-effectiveness ratio (ICER) and quality-adjusted life years (QALYs) associated with low dose CT screening. The ICER was $52,000 per life-year gained and the $81,000 per QALY gained. These values were very sensitive to variations in the scr
October 16, 2014
Because of the observation that already debilitated pts who undergo lung resection become even more debilitated afterwards, the authors conducted a randomized trial of endurance and strength training for 20 wks after major lung resection. Training significantly improved peak VO2, DLCO, strength, endurance, and muscle mass compared to controls. Qual