The authors demonstrated substantial concordance between sequencing of 39 genes in a liquid assay and routine diagnostic testing in tissue in 82 patients. Agreement was 98%, and the primary reason for failure was low levels of circulating DNA in the plasma. Sensitivity was 70%, and specificity was 100%. The system offers accurate identification of
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Lung Cancer - Other
October 2, 2017
August 2, 2017
This retrospective study of the association of BMI to long-term survival after resection of NSCLC identified BMI > 30kg/m2 as an independent predictor of survival. In a propensity score matched set, patients with BMI >30 had better survival than those with a BMI of 25 (p=0.003). The reason for this relationship remains to be elucidated.
August 2, 2017
This is an excellent summary of progress during the past year in all aspects of lung cancer, from prevention/detection through molecular therapies and future perspectives. Each section is written by a handful of international experts.
February 24, 2016
Routine use of PET scans to follow up asymptomatic patients do not affect survival, according to this retrospective analysis of a cohort of 97,152 lung cancer and 4,446 esophageal cancer patients. They compared high and low level of use of PET centers, and found no differences in two-year survival.
August 11, 2015
This single institution retrospective study evaluated the relationship of adenocarcinoma subtype to long-term survival after resection of stage I lung cancer. Patients with solid-predominant tumors experienced recurrences earlier, more often in distant sites, and more often in multiple locations. This subtype was also independently associated with
July 16, 2015
In order to improve the diagnostic accuracy of bronchoscopy for lung cancer, epithelial cells were collected from normal appearing mucosa in the mainstem bronchus of patients suspected of having lung cancer during diagnostic bronchoscopy. The samples were evaluated with a gene expression classifier. 43% of the standard examinations were nondiagnost
July 9, 2015
Stephen Hazelrigg, Neil Christie, and Hiran Fernando discuss the use of stereotactic body radiation therapy (SBRT) in the treatment of lung cancer.
June 24, 2015
The ELCAP data set was evaluated for pts identified with non-solid nodules at baseline or during follow-up. 2392 (4.2%) pts had nonsolid nodules at baseline, of which 73 were diagnosed as adenocarcinoma. A new nodule was identified in an additional 485 (0.7%) pts, of whom 11 were diagnosed with adenocarcinoma. Nonsolid nodules improved in 66% of
May 22, 2015
In this retrospective review of 336 patients treated surgically for early stage NSCLC, the prognostic value of PET SUV was evaluated. Risks of recurrence and death increased steadily as SUV increased.
May 19, 2015
Pts with suspected lung cancer underwent sampling of normal-appearingbronchial epithelial cells in the main bronchi, unrelated to the suspected tumor. Gene expression was analyzed and classified. Classification for cancer was about 75% accurate.