Using UNOS data, the authors evaluated long-term survival and primary graft failure (PGF) comparing cohorts with less than and more than 6 hours of graft ischemia. 31% of patients had prolonged ischemia. There was no association between prolonged ischemia and PGF or survival at 1 and 5 years.
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Lung Transplant
June 18, 2015
March 3, 2015
The impact of the new Lung Allocation Score (implemented in 2005) on outcomes of single and double lung transplants for IPF and COPD was explored. After controlling for confounders with propensity score techniques, DLT was associated with better graft survival for IPF but there was no difference in graft survival between DLT and SLT for COPD patient
March 2, 2015
This study evaluated outcomes of synchronous or delayed kidney Tx in patients with lung or heart-lung transplant. Delayed living-donor kidney Tx was associated with favorable outcomes. Synchronous cadaver kidney transplant at the time of heart-lung or lung transplant was clinically challenging.
January 26, 2015
In this retrospective study of 173 lung transplants performed at Loyola University, investigators found a correlation between heavy alcohol use in lung transplant donors and risk of developing severe primary graft dysfunction. Those recipients had an 8.7 times higher risk than patients who received lungs from donors who did not drink.
January 24, 2015
The Columbia group performed a retrospective analysis of 46 balloon atrial septostomies in 32 patients with severe and medically refractory PAH from 2002-2013. There were no procedural deaths or complications. BAS was safely used as a bridge to lung transplantation or to alleviate right heart failure symptoms and/or syncope.
November 2, 2014
Ex-vivo lung reperfusion was employed to recondition marginal or rejected lung grafts. Eight out of 11 lungs were deemed suitable for transplantation after treatment. Results with regard to primary graft dysfunction were comparable to those of 28 regular transplantations.
May 28, 2014
May 6, 2014
Outcomes of patients undergoing lung transplant after LVRS were compared to those of patients undergoing LVRS or transplant alone. OR time and LOS were longer in the combined group. Morbidity and mortality were similar among the groups. Post-transplant survival was substantially lower in the combined group. However, if time from LVRS to transplan
April 14, 2014
There are few instruments to assess patient-centered outcomes after lung transplant. The authors developed and validated a shortened version of the valued life activities disability scale for this population. The scale was devised using 140 lung transplant participants and was validated in 84 patients before and after transplant. The instrument ta
March 24, 2014
On March 20, 2014, a panel of the FDA gave unanimous approval for use of an ex-vivo perfusion system for improving the quality of explanted lungs prior to transplantation. If this recommendation is followed by the FDA, such devices could be used clinically under IRB protocols.