Hypertrophic Obstructive Cardiomyopathy: The Mayo Clinic Experience

This study details the short- and long-term outcomes for more than 3,000 patients who underwent septal myectomy for hypertrophic cardiomyopathy at the Mayo Clinic in Rochester, United States, from 1993 to 2016. In over 90% of severely symptomatic patients, relief of left ventricular outflow tract obstruction resulted in clinical improvement by at least two functional classes and reduced or eliminated symptoms of dyspnea, angina, and/or syncope.

The authors also outline outcomes for the transapical approach for basal obstruction with systolic anterior motion in 115 patients between 1993 and 2012, with all patients demonstrating postoperative gradient relief without the complication of an apical aneurysm or ventricular septal defect. These results emphasize that excellent outcomes can result from myectomy performed in experienced centers, with early mortality for isolated septal myectomy being less than 1%.