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Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction

Tuesday, February 2, 2016

Submitted by

Aristotle Protopapas

Source

Source Name: The New England Journal of Medicine

Source URL: http://www.nejm.org/doi/full/10.1056/NEJMoa1510774?query=TOC#t=articleDiscussion

Author(s)

Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, LeWinter MM, Joseph SM, Shah SJ, Semigran MJ, Felker GM, Cole RT, Reeves GR, Tedford RJ, Tang WH, McNulty SE, Velazquez EJ, Shah MR, Braunwald E

This randomized trial (NEAT-HFpEF) of 110 subjects (59 placebos) disproves, by clinical and biological markers, the utility of nitrates for exercise tolerance. This is a subset of cardiac failure patients we are likely to encounter in general cardiothoracic surgical practice.