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Lung Transplant Outcome From Selected Older Donors (≥70 Years) Equals Younger Donors (<70 Years)

Thursday, January 2, 2025

Submitted by

Akshay Patel

Source

Source Name: Annals of Surgery

Source URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10414152/

Author(s)

Cedric Vanluyten, Christelle M Vandervelde, Robin Vos, Jan Van Slambrouck, Steffen Fieuws, Paul De Leyn, Philippe Nafteux, Herbert Decaluwé, Hans Van Veer, Lieven Depypere, Yanina Jansen, An-Lies Provoost, Arne P Neyrinck, Catherine Ingels, Bart M Vanaudenaerde, Laurent Godinas, Lieven J Dupont, Geert M Verleden, Dirk Van Raemdonck, Laurens J Ceulemans

This study evaluates the outcomes of bilateral lung transplantation (LTx) using grafts from donors aged 70 years or older, compared with those from younger donors. Conducted at a single center in Leuven, Belgium, the retrospective cohort study included 69 older donors, matched 1:1 with younger donors based on key variables. Primary endpoints included the incidence of primary graft dysfunction (PGD) grade 3 within 72 hours post-transplant, five-year patient survival, and chronic lung allograft dysfunction (CLAD)-free survival.

There were no significant differences in PGD-3 rates (26 percent in older donors versus 29 percent in younger donors), five-year survival (73.6 percent versus 73.1 percent), or CLAD-free survival (51.5 percent versus 59.2 percent).

Carefully selected older donors (mean age 74 years) demonstrated similar short- and long-term outcomes as younger donors.

The study indicates that using lungs from donors aged 70 years or older can effectively address organ shortages, thus expanding the donor pool, without compromising recipient outcomes.