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Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study

Thursday, June 30, 2016

Submitted by

Mark Ferguson

Source

Source Name: Journal of Thoracic Diseases

Source URL: http://www.jto.org/article/S1556-0864%2816%2930091-0/fulltext

Author(s)

Ryutaro Kakinuma, Masayuki Noguchi, Kazuto Ashizawa, Keiko Kuriyama, Akiko Miyagi Maeshima, Naoya Koizumi, Tetsuro Kondo, Haruhisa Matsuguma, Norihisa Nitta, Hironobu Ohmatsu, Jiro Okami, Hiroshi Suehisa, Taiki Yamaji, Ken Kodama, Kiyoshi Mori, Kouzo Yamada, Yoshihiro Matsuno, Sadayuki Murayama, Kiyoshi Murata

The multi-institutional prospective study evaluated the behavior of pure GGOs (85%), heterogeneous GGOs (part solid only on CT lung windows; 7%), and part-solid GGOs on soft-tissue windows. Among pure GGOs, 6.6% advanced to one of the other categories during a mean follow-up period of 4.3 years. Of the 35 pure GGOs that were resected, none was an invasive cancer. Invasive adenocarcinoma was identified in only 1% of all nodules, and only among the part solid nodules.