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Objective Measurement and Clinical Significance of TILs in Non–Small Cell Lung Cancer

Thursday, March 12, 2015

Submitted by

Marcelo Jimenez

Source

Source Name: Journal of the National Cancer Institute

Source URL: http://jnci.oxfordjournals.org/content/107/3/dju435.abstract?etoc

Author(s)

Kurt A. Schalper, Jason Brown, Daniel Carvajal-Hausdorf, Joseph McLaughlin, Vamsidhar Velcheti, Konstantinos N. Syrigos, Roy S. Herbst and David L. Rimm

Samples from tissue microarrays of 552 NSCLC patients were analyzed to measure the levels of 3 different tumor-infiltrating lymphocytes (TILs): CD3, CD8, and CD20. An elevated level of CD3 or CD8 was associated with longer survival. This finding might be useful to evaluate response or assess the local immune effect of anticancer immune inhibitors.