ALERT!

This site is not optimized for Internet Explorer 8 (or older).

Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.

Patterns of Recurrence After Surgery Alone Versus Preoperative Chemoradiotherapy and Surgery in the CROSS Trials

Monday, February 10, 2014

Submitted by

Mark Ferguson

Source

Source Name: Journal of Clinical Oncology

Source URL: http://jco.ascopubs.org/content/32/5/385?cmpid=jco_etoc_10February2014

Author(s)

V Oppedijk, A van der Gaast, JJB van Lanschot, P van Hagen, R van Os, CM van Rij, MJ van der Sangen, JC Beukema, H Rutten, PH Spruit, JG Reinders, DJ Richel, MI van Berge Henegouwen, MCCM Hulshof

The CROSS trials randomized pts with esophageal cancer or GEJ cancer to surgery vs induction chemoradiotherapy (CRT) followed by surgery. Prior studies reported a significant improvement in survival and freedom from recurrence associated with induction therapy. In this report, CRT reduced locoregional recurrence from 34% to 14% and reduced peritoneal carcinomatosis from 14% to 4%. Local recurrence within the RT field occurred in only 5% of patients.