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Radiation to the Gastric Fundus Increases the Risk of Anastomotic Leakage After Esophagectomy

Wednesday, November 23, 2016

Submitted by

Mark Ferguson

Source

Source Name: Annals of Thoracic Surgery

Source URL: http://dx.doi.org/10.1016/j.athoracsur.2016.08.027

Author(s)

Lucas Goense, Peter S.N. van Rossum, Jelle P. Ruurda, Marco van Vulpen, Stella Mook, Gert J. Meijer, Richard van Hillegersberg

This retrospective single institution study evaluated the relationship between radiation dose to the gastric fundus and the incidence of esophageal anastomotic leak after esophagectomy for cancer. The leak rate was 26%. Pts with a leak had a significantly higher RT dose to the gastric fundus. Using a cut point of 31.4 Gy, leak rates were 43% vs 15% for the high and low dose radiation exposure. Radiation dose was an independent predictor of anastomotic leak in multivariable analysis.