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Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

Saturday, February 1, 2020

Submitted by

Mark Ferguson

Source

Source Name: New England Journal of Medicine

Source URL: https://www.nejm.org/doi/full/10.1056/NEJMoa1911793

Author(s)

Harry J. de Koning, Carlijn M. van der Aalst, Pim A. de Jong, Ernst T. Scholten, Kristiaan Nackaerts, Marjolein A. Heuvelmans, Jan-Willem J. Lammers, Carla Weenink, Uraujh Yousaf-Khan, Nanda Horeweg, Susan van ’t Westeinde, Mathias Prokop, Willem P. Mali, Firdaus A.A. Mohamed Hoesein, Peter M.A. van Ooijen, Joachim G.J.V. Aerts, Michael A. den Bakker, Erik Thunnissen, Johny Verschakelen, Rozemarijn Vliegenthart, Joan E. Walter, Kevin ten Haaf, Harry J.M. Groen, and Matthijs Oudkerk

Individuals at high risk for lung cancer were randomized to low dose CT screening (years 0, 1, 3, and 5.5) or observation. At 10 years the cumulative rate ratio for lung cancer death was 0.76 in the screened population of men (p=0.01) and 0.67 in the screened population of women, demonstrating a strong benefit for screening.