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Journal and News Scan
In this official statement, the European Society of Cardiology advocates for the evolution of the Medical Device Regulation (MDR) system to facilitate priority access for innovative devices addressing unmet needs and orphan cardiovascular medical devices in the European Union. It also calls for global regulatory harmonization to streamline cardiovascular medical device authorization across jurisdictions, enabling reprocessing of single-use devices, and encouraging early feasibility studies to assess initial safety and performance, thus accelerating device development and adoption. This report presents a proposal to improve medical device authorization worldwide while protecting patient safety.
Heart transplants from donation after circulatory death (DCD) donors are well-established for adults in the United Kingdom, but extending this practice to pediatric heart transplants has been slow and difficult despite a severe donor shortage. Barriers include ethical concerns, technology gaps, and logistical challenges. This article urges action to establish a sustainable pediatric DCD cardiac program in the United Kingdom and offers insights for other countries facing similar issues.
This study reported the initial experiences of 115 patients who underwent robot-assisted thoracic surgery using the da Vinci single-port robotic system. The procedures included thymectomy, mediastinal mass excision, anatomical pulmonary resection, esophagectomy, and esophageal tumor enucleation. No conversions to thoracotomy or sternotomy were required, and only one patient required conversion to video-assisted thoracic surgery, with minimal postoperative complications. The findings suggest that single-port robot-assisted thoracic surgery is feasible and safe, with the potential for expanded use as robotic technology continues to advance.
This study compared perioperative and oncological outcomes between modified subxiphoid video-assisted thoracoscopic surgery (VATS) thymectomy and median sternotomy thymectomy for locally advanced thymic malignancies. A propensity score–matched analysis of 144 patients revealed that the VATS approach resulted in shorter operative duration, less blood loss, faster recovery, and fewer complications, with no significant difference in complete resection rates. Survival analyses indicated similar recurrence-free and overall survival between the two groups. These findings suggest that modified subxiphoid VATS thymectomy is a safe and effective alternative for selected patients, although further prospective studies are needed for long-term evaluation.
This retrospective single-center study evaluates the outcomes of isolated single lung transplants (SLT) (one usable, one declined lung) compared to split SLTs (both lungs are used for different recipients). Approximately 80 percent of lung transplants are bilateral, leading to a paucity of literature on isolated SLT outcomes. A total of 164 patients underwent split SLT, and 271 received an isolated SLT. Survival rates did not differ significantly between isolated and split SLT recipients (HR 0.97, CI 0.72–1.33, p = 0.87), with no significant differences found in the need for ECMO, postoperative ventilation, or length of hospitalization. These findings suggest that isolated SLT is a safe and viable option, offering survival outcomes comparable to those of split SLT. This could indicate that well-selected isolated donor lungs can be used safely, expanding the limited donor pool and reducing waitlist mortality.
This group presents a standardized, step-by-step technique for robotic-assisted lung transplantation. The authors describe port placement strategies, dissection techniques, and sequential anastomosis to optimize surgical precision while minimizing trauma. The study highlights key benefits of robotic lung transplantation, including reduced postoperative pain, faster recovery, and improved wound healing. Special considerations, such as anesthetic management, extracorporeal membrane oxygenation (ECMO) strategies, and gas insufflation techniques, are also addressed to enhance surgical feasibility and patient safety.
This research is highly relevant to the cardiothoracic surgery community as it introduces a minimally invasive alternative to conventional lung transplantation, potentially revolutionizing the field. The findings provide valuable insights into adopting robotic-assisted techniques, improving surgical outcomes, and expanding the role of advanced technology in complex thoracic procedures.
Infective endocarditis (IE) remains one of the most challenging diseases of modern times. It is associated with high mortality and morbidity despite significant improvements in diagnostic and surgical skills, and antibiotic pretreatment.
Every study contributes to the knowledge of this often-lethal disease, but one of the ongoing challenges is determining which patients are likely to survive and how survival in general can be improved. Currently, between 52.9 percent and 58.9 percent of patients with IE have a theoretical indication for surgery. However, valve surgery is only performed in approximately 40 percent of cases. Several scoring systems, such as EuroScore I and II, PALSUSE, Risk-E, Costa, De Feo-Cotrufo, AEPEI, STS-risk, STS-IE, APORTEI, and ICE-PCS, have been evaluated to assess the operability of a given patient, but the utility of these scores remains questionable.
While 30-day mortality is considered an outdated tool for evaluating surgical quality, and abandoning this concept has been suggested as mortality seems to increase after 30 days, the authors decided to use it nonetheless, as none of the mentioned scores are sufficiently conclusive. To justify this approach, all-hospital death was also included in the analysis. Thus, a retrospective analysis of the endocarditis registry was performed to evaluate risk factors for 30-day mortality and, in turn, explore the question of operability and the potential benefit of surgical intervention for these critically ill patients.
Researchers have shown that patches of muscle grown from stem cells can help repair a failing heart. A laboratory-grown biological transplant with the potential to stabilize and strengthen the heart muscle can be implanted onto the heart surface. The treatment is not intended to replace the need for a full transplant but can assist people with advanced heart failure who are waiting for a heart transplant, bridging the time until a donor's heart becomes available. In this clinical trial, the procedure was tested on a 46-year-old woman with heart failure who underwent an operation to implant 10 patches containing 400 million cells on the surface of her heart. Her condition remained stable for three months, allowing enough time for her to receive a heart transplant. Scientists who examined her explanted heart after the transplantation found that the implanted muscle patches had remained in place and formed blood vessels. So far, researchers have implanted similar muscle patches in 15 individuals.
Proper preservation of the myocardium during intraoperative ischemia is a critical predictor of satisfactory clinical outcomes. However, there can be a wide degree of diversity in myocardial damage among patients receiving the same cardioplegic solution. The efficacy of cardioplegia-induced arrest can be affected by other factors, which may become apparent in more demanding clinical scenarios, such as in patients with impaired contractility at baseline. This study aims to identify these factors and assess their impact on postoperative myocardial damage.
Cardioprotection is important in patients with heart failure, as the effects of inadequate cardioprotection are particularly pronounced in this patient population. Two well-established protocols are used for cardioplegia in these cases: del Nido cardioplegia (DN) and cold blood cardioplegia (CB). Several prospective trials have evaluated the use of the del Nido protocol, but none specifically address patients with significantly impaired contractility. Therefore, current guidelines on cardiopulmonary bypass in adult cardiac surgery recommend applying the DN protocol in low-risk cases with short aortic cross-clamp times (CCTs) to minimize surgical interruptions caused by repeated perfusion of cardioplegia. Blood cardioplegia has a longer history, and its efficacy is well documented. Many surgeons consider it the most efficient protocol, particularly in ischemic or damaged myocardium, as supported by clinical studies.
The decision on whether to use DN or CB is made by the surgeon, with each case treated individually. Factors that are taken into consideration include the complexity of the procedure, the estimated duration of the CCT, the risk of fluid overload in patients with heart failure or kidney disease, the potential for allergies to lidocaine, the rationale for additional cardioplegia doses (selective graft perfusion), and the patient's blood morphology parameters.
Due to the differences in protocols, it is necessary to address the entire cohort and evaluate the impact of the analyzed determinants for each cardioplegia method separately. The leading hypothesis is that patients' baseline characteristics and operative determinants may impact the efficacy of cardioprotection during surgery, but this effect may vary depending on the solution used.
This study explores how disparities between actual and predicted total lung capacity (TLC) in patients with interstitial lung disease (ILD) affect lung function parameters and long-term outcomes after lung transplantation. A total of 170 ILD patients who underwent lung transplantation between 2011 and 2022 were included. They were stratified based on the preoperative median ratio of recipient actual to predicted (a/p) TLC. Of these, 85 patients had a low a/p TLC ratio corresponding to <0.55, while the remaining 85 patients had a high a/p TLC ratio of ≥0.55. There were no significant differences between the two groups in tracheostomy and reintubation rates, mechanical ventilation duration, ICU and hospital stays, or five-year overall survival. Although early post-LTx lung function was better in the high a/p TLC ratio group, long-term outcomes were similar in both groups. These findings may suggest remodeling of chest wall compliance in severely restricted ILD patients after LTx.