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Journal and News Scan
The optimal revascularization strategy after extracorporeal cardiopulmonary resuscitation (ECPR) remains unclear, with limited existing data. This study compared outcomes for patients who underwent coronary artery bypass grafting (CABG) and those who received percutaneous coronary intervention (PCI) after ECPR using databases from two referral centers. Forty patients in each category were compared. Researchers found that the CABG group had better early outcomes (hospital survival- 56.4 percent vs 32.4 percent, p = 0.04 and success of ECPR weaning: 71.1 percent vs 48.7 percent, p = 0.05) compared to the PCI group. Late outcomes were similar among groups, although the PCI group appeared to have more endovascular interventions.
Lung transplantation is limited by the availability of donors, with relative scarcity of organs. Aspiration prior to donation is one reason donor organs might be discarded due to concern for acute lung injury, which adversely impacts graft survival. This cellular injury is mediated by neutrophil extracellular traps (NETs), and removal of these inflammatory structures has been postulated to reduce aspiration associated with cellular injury. This article studied a NET removal device in porcine lungs and found lower inflammatory markers including cytokines, cell free DNA, and tissue edema. This article aims to potentially increase the transplant lung donor pool by highlighting this area of study.
Minimally-invasive pulmonary segmentectomy is an effective method for treating selective cases while preserving lung parenchyma and minimizing perioperative morbidity and length of hospital stay. A fully thoracoscopic multiport approach is often preferred due to its straightforwardness and flexibility, allowing adaptation to unexpected intraoperative findings.
The S1 (apical) segment of the right upper lobe poses challenges for a conventional anterior approach due to its complex vascular anatomy. A posterior approach may address these challenges by providing direct access to the segmental bronchus and better alignment for dissection for the apical artery, however, success depends on individual anatomy.
The utility of operating room extubation (ORE) after cardiac surgery over fast-track extubation (FTE) within 6 hours remains contested. The authors hypothesized ORE would be associated with equivalent rates of morbidity and mortality, relative to FTE. They found that ORE was associated with similar or improved outcomes compared to FTE. The study covering 669,099 patients across 1,069 hospitals revealed that ORE had lower postoperative mortality rates for coronary artery bypass grafting, aortic valve replacement, and mitral valve replacement. These findings suggest that ORE can be safe and potentially beneficial, indicating a need for further research to optimize patient selection and explore the benefits of ORE through randomized trials.
Chronic lung allograft dysfunction (CLAD) is associated with significant morbidity after lung transplantation, however, at the time of diagnosis of CLAD, the disease process has usually adversely impacted graft function. The authors studied a scoring system based on the Airway Inflammation 2 (AI2) gene set and found that this score predicted time to graft failure as well as retransplant free survival in patients with CLAD, as compared to a validation cohort that included non-CLAD patients. Although there may be a component of survival bias during matching, this is a highly interesting area of research that could have important clinical implications in early identification of CLAD.
This consensus statement disseminated by the International Society for Heart and Lung Transplantation (ISHLT) focuses on the prevention and management of hemocompatability-related adverse events (HRAEs) in patients with durable, continuous-flow left ventricular assist devices (CF-LVAD). As survival in this group of patients continues to improve with advances in technology, HRAEs remain a concern. The ISHLT summarizes the literature in this field and shares several recommendations including management of antiplatelet agents, oral anticoagulation, management of high-risk patients, and management of bleeding or clotting events based on different existing devices.
Congenital and pediatric cardiac surgery are among the most complex, high-stake medical specialties, which requires exceptional cognitive and technical skills. Despite advances in technology and patient safety, the training for future surgeons in this field faces significant challenges. Issues include the increasing complexity of surgeries, reduced opportunities for simpler cases, strict work hour regulations, and public scrutiny of outcomes. These factors contribute to a crisis in training, with many trainees and young surgeons expressing dissatisfaction.
Mentorship is crucial in overcoming these challenges. It involves a stepwise approach to teaching surgical skills, ongoing guidance during early years of practice, and leadership training for managing interdisciplinary teams. Effective mentorship not only improves technical proficiency but also enhances emotional intelligence and resilience. Despite the lack of tangible rewards and the significant time commitment required, mentoring enriches both the mentor and mentee, ultimately benefiting patient care and advancing the field.
Penetrating thoracic injuries have high risks of morbidity and mortality, with severe pulmonary vascular and bronchial injuries sometimes necessitating post-traumatic pneumonectomy and perioperative ECMO support due to right ventricular and respiratory failure. This case describes a male with a penetrating thoracic injury presenting with a massive right hemothorax and active bleeding, requiring ligation of the right pulmonary hilum. He subsequently developed right ventricular dysfunction and ARDS, necessitating a dynamic hybrid ECMO configuration to support his recovery. This case highlights that ECMO support can reduce mortality and complications in such severe injuries. Effective management requires a multidisciplinary team for optimal outcomes in severely compromised patients.
Ischemic cardiomyopathy (ICM) causes more than 60 percent of congestive heart failure cases, leading to high morbidity and mortality. Myocardial revascularization is vital for patients with left ventricular dysfunction (LVD) and an ejection fraction (LVEF) ≤ 35 percent, aiming to improve survival rates and quality of life. Despite its importance, randomized clinical trials often exclude these patients, relying on observational data. A recent review evaluated surgical revascularization strategies, highlighting ONCABG for multivessel disease in LVD patients with LVEF < 35 percent, and OPCAB for older, high-risk patients. Techniques such as internal thoracic artery skeletonization, BITA, and postoperative glycemic control are crucial for managing risks. Total arterial revascularization improves long-term survival, while hybrid revascularization reduces hospital stays and costs. This review emphasizes the need for tailored revascularization strategies in severe LVD patients.
Recent percutaneous revascularization of unprotected left main disease has generated a debate about the outcomes after percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) disease. The authors in this metanalysis used four randomized control trials and 10 adjusted observational studies, which total 24,767 patients to compare PCI with CABG. Within the limitations of a meta-analysis, which includes the limitations and inherent biases of all the individual studies involved, PCI was found to be associated with a higher risk of all-cause death and repeat revascularization compared to CABG. In the elderly population, PCI and CABG appeared to have similar outcomes, but there was a higher risk of major adverse cardiac events (MACE) with PCI.