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Journal and News Scan
The study of acute aortic syndromes, particularly the study of aortic mechanics, is quite challenging due to the dynamic nature of the aorta, complex and variable geometry, and the presence of a valve in constant motion. Several theoretical and mechanical models have been developed previously; however, all have limitations thus affecting the quality of decision making. The authors of this excellent paper propose new mathematical models to more closely mimic aortic mechanics, including discussion of practical models to test these hypotheses. While a large knowledge gap still exists, this paper aims to bridge the gap further.
Current intraoperative methods for evaluating aortic valve repair often fail to predict the final echocardiographic outcome. The authors developed an aortic valve visualization and pressurization (AVP) device for use during cardioplegia and present results from its use in 24 patients undergoing valve sparing root replacement. The authors conclude that the AVP device can be a useful tool for intraoperative evaluation of the aortic valve, helping to make the result of surgery more predictable.
This paper utilized the Delphi method to establish interdisciplinary consensus for the initial investigations, diagnostic imaging, referral pathway and interhospital transfer for patients with acute aortic syndrome. The authors represent the coming together of experts from the multidisciplinary team, as well as members of the public, including patient representatives. This comes following the global patient-led work of THINK AORTA.
The incidence, predictors, and prognostic impact of rehospitalization following transcatheter aortic valve implantation (TAVI) has not been widely investigated and reported. This information is especially missing based on real-world practice data. Hence, the authors retrospectively analyzed a total of 1,397 patients who underwent TAVI between 2016 and 2020 in East Denmark. The medical records of all patients were reviewed to validate rehospitalizations up to one year after discharge from the index TAVI. A total of 615 patients (44 percent) had an unplanned rehospitalization within the first year after TAVI. The incidence of unplanned rehospitalization rate was three times higher in the early post-TAVI period (i.e., within 30 days) compared with the late post-TAVI period (i.e., 30 days to 1 year; 2.5 vs. 0.8 per patient-year, respectively; P < 0.001). Early rehospitalization was most frequently procedure related, whereas late rehospitalization was mostly related to baseline comorbidities. Early and late heart failure related rehospitalization was associated with a considerably higher one and five-year mortality risk (hazard ratio (HR) of 4.3 and 3.2 for 1-year mortality and HR of 3.2 and 2.9 for 5-year mortality, respectively; P < 0.001). Given the elevated frequency of rehospitalization following TAVI and the poor long-term survival associated with heart failure related rehospitalization, the authors conclude that TAVI trials should include rehospitalization as a major study endpoint.
In this LACES “Experts’ Insights” interview, Dr. Michael Borger, co-chair of the recently published 2023 ESC/EACTS Endocarditis Guidelines, briefly summarizes the most important take-home messages and changes of the guidelines.
This article looks at the application of prognostic models within cardiothoracic surgery, and medicine in general, using a televised UK dance competition where professional dancers are paired with celebrities as an illustration. The authors use available data from previous series to make predictions about the outcome of the competition and highlight the pitfalls of misapplication of prognostic models, particularly when extrapolating conclusions from demographic data alone.
The ISCHEMIA trial has caused heated discussion in the cardiovascular field, with its results being used to downgrade coronary artery bypass grafting (CABG) recommendations in recent guidelines. The authors of this paper performed a detailed re-analysis of the ISCHEMIA trial and critically examined its findings. Several factors are judged likely to have diluted the potential survival advantage associated with CABG. The authors concluded that the results of ISCHEMIA have been misinterpreted, that they are aligned with previous evidence and should not be used to downgrade recommendations for CABG.
This article is a registry review form an international voluntary registry. The retrospective historical data can be juxtaposed favorably with the recently published article on acute dissection in Denmark from a compulsory national registry. The main strength of the paper is the succinct discussion.
Non-inferiority study designs are frequently used in randomized controlled trials (RCT) comparing transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). However, the long-term outcomes of TAVR are unknown, and the concept of non-inferiority is challenging to define and assess. This systematic review and meta-analysis published in Interdisciplinary Cardiovascular and Thoracic Surgery (ICVTS) compares TAVR and SAVR, specifically emphasizing the non-inferiority margin for five-year all-cause mortality. To this end, the authors performed a systematic search in three electronic databases. A total of eight RCTs (n = 8,698 patients) comparing TAVR and SAVR were included. Bayesian methods were implemented to evaluate the posterior probability of non-inferiority at different trial non-inferiority margins. The primary study outcomes were five-year actuarial all-cause mortality and the probability of non-inferiority at various transformed trial non-inferiority margins. Kaplan-Meier-derived five-year survival was 61.6 percent (95 percent CI 59.8–63.5 percent) for TAVR and 63.7 percent (95 percent CI 61.9–65.6 percent) for SAVR. The posterior median relative risk for all-cause mortality of TAVR was 1.14 compared to SAVR. The posterior probability of a mortality difference in favor of SAVR was 99.9 percent. The authors concluded that the non-inferiority of TAVR compared to SAVR is unlikely after five years in terms of all-cause mortality.
Minimally invasive mitral valve surgery (MIMVS) is feasible and safe, but its uptake has lagged worldwide. The authors conducted a detailed survey of 75 surgeons, of whom 32 (42 percent) completed the survey. All who completed the survey performed more than 25 MIMVS cases annually. 62 percent used a fully endoscopic approach, whereas 52 percent had used endoscopically assisted strategies. Smaller proportions had used direct visualization (17 percent) or a robot (20 percent). There was wide variability in views on the necessary training and approach to MIMVS, suggesting that consensus guidelines should be established.