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Journal and News Scan

Source: The Annals of Thoracic Surgery
Author(s): Martin Czerny, Martin Grabenwöger, Tim Berger, Victor Aboyans, Alessandro Della Corte, Edward P. Chen, Nimesh D. Desai, Julia Dumfarth, John A. Elefteriades, Christian D. Etz, Karen M. Kim, Maximilian Kreibich, Mario Lescan, Luca Di Marco, Andreas Martens, Carlos A. Mestres, Milan Milojevic, Christoph A. Nienaber, Gabriele Piffaretti, Ourania Preventza, Eduard Quintana, Bartosz Rylski, Christopher L. Schlett, Florian Schoenhoff, Santi Trimarchi, Konstantinos Tsagakis, EACTS/STS Scientific Document Group, Matthias Siepe, Anthony L. Estrera, Joseph E. Bavaria, Davide Pacini, Yutaka Okita, Arturo Evangelista, Katherine B. Harrington, Puja Kachroo, G. Chad Hughes

These guidelines, issued by the European Association for Cardio-Thoracic Surgery (EACTS) and The Society of Thoracic Surgeons (STS), address the management of the aortic organ. This is an essential and comprehensive resource for cardiothoracic surgeons, as it presents up-to-date evidence on pathophysiology, natural history, diagnosis, management, and specific surgical techniques related to aortic surgery. Additionally, the guidelines provide a list of areas that require further research, such as the identification of biomarkers, determining the extent of repair in acute type A aortic dissections, the use of endovascular therapies in patients with heritable aortic disease, and the development of standardized protocols for imaging, measurement of the aorta and follow-up.

Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Author(s): Hristo Kirov, Tulio Caldonazo, Angelique Runkel, Johannes Fischer, Panagiotis Tasoudis, Murat Mukharyamov, Gianmarco Cancelli, Michele Dell’Aquila, Torsten  Doenst

Minimally invasive cardiac surgery (MICS) is increasingly popular due to its reduced invasiveness compared to traditional methods. A key component of MICS is the establishment of cardiopulmonary bypass, which is typically achieved by cannulating the groin. Traditionally, this process requires a second surgical incision to access the femoral vessels. However, advancements in arterial closure devices have made percutaneous cannulation a viable alternative.  
 
This is a meta-analysis and systematic review comparing percutaneous versus surgical groin cannulation in minimally invasive cardiac surgery. The review incorporated data from three databases and included five studies with a total of 2,038 patients. It found that surgical cannulation was linked to a higher incidence of access site complications, including wound and lymphatic issues, and longer procedural duration. No significant differences were observed between the two methods, including perioperative mortality, stroke, or hospital length of stay. This review underscores the benefits of percutaneous techniques in reducing complications and optimizing surgical efficiency in minimally invasive cardiac procedures. 

Source: European Heart Journal
Author(s): Christiaan Vrints, Felicita Andreotti, Konstantinos C Koskinas, Xavier Rossello, Marianna Adamo, James Ainslie, Adrian Paul Banning, Andrzej Budaj, Ronny R Buechel, Giovanni Alfonso Chiariello, Alaide Chieffo, Ruxandra Maria Christodorescu, Christi Deaton, Torsten Doenst, Hywel W Jones, Vijay Kunadian, Julinda Mehilli, Milan Milojevic, Jan J Piek, Francesca Pugliese, Andrea Rubboli, Anne Grete Semb, Roxy Senior, Jurrien M ten Berg, Eric Van Belle, Emeline M Van Craenenbroeck, Rafael Vidal-Perez, Simon Winther, ESC Scientific Document Group

The updated guidelines for managing chronic coronary symptoms (CCS) provide a framework for diagnosing and treating suspected and confirmed cases of CCS. They emphasize using a risk factor-weighted model to better estimate the likelihood of obstructive coronary artery disease (CAD), which improves upon the previous 2019 ESC model by more accurately classifying patients into low-risk categories where further testing might not be needed. The guidelines include a new diagnostic algorithm for moderate or high-risk patients and expand on the diagnosis and treatment of angina with no or nonobstructive CAD (ANOCA-INOCA). They offer detailed recommendations for anti-anginal medications, therapies to prevent events, adherence strategies and the selection of revascularization techniques based on recent research. The guidelines also address management strategies for recurrent or refractory angina and ischemia.  

Source: Journal of the American College of Cardiology
Author(s): Adam B. Greenbaum, Hiroki A. Ueyama, Patrick T. Gleason, Jaffar M. Khan, Christopher G. Bruce, Rim N. Halaby, Toby Rogers, George S. Hanzel, Joe X. Xie, Isida Byku, Robert A. Guyton, Kendra J. Grubb, John C. Lisko, Nikoloz Shekiladze, Errol K. Inci, Elizabeth A. Grier, Gaetano Paone, James M. McCabe, Robert J. Lederman, and Vasilis C. Babaliaros

Researchers explore the use of a novel transcatheter electrosurgical technique, SESAME, for treating left ventricular outflow tract (LVOT) obstruction. This procedure, designed to mimic surgical myotomy, was tested on 76 patients between 2021 and 2023. SESAME successfully reduced LVOT gradients in hypertrophic cardiomyopathy (HCM) patients and improved LVOT dimensions to facilitate transcatheter mitral and aortic valve replacements. The procedure showed a high success rate with a low incidence of serious complications, though some patients required permanent pacemakers. SESAME appears promising for both reducing obstruction in HCM and aiding in valve implantation procedures.  

Source: European Journal of Cardiothoracic Surgery
Author(s): Mateo Marin-Cuartas, Manuela De La Cuesta, Carolyn Weber, Elisabeth Krinke, Artur Lichtenberg, Asen Petrov, Christian Hagl, Hug Aubin, Klaus Matschke, Mahmoud Diab, Maximilian Luehr, Payam Akhyari, Philipp Schnackenburg, Sems-Malte Tugtekin, Shekhar Saha, Torsten Doenst, Thorsten Wahlers, Michael A Borger, Martin Misfeld

The authors aimed to analyze the impact of preoperative septic cerebral embolism on early and late postoperative outcomes in patients with infective endocarditis (IE) undergoing valve surgery. This study utilized data from the Clinical Multicentric Project for Analysis of Infective Endocarditis in Germany (CAMPAIGN) registry, which includes patients with IE who underwent valve surgery between 1994 and 2018 at six German centers. Patients were categorized based on the presence or absence of preoperative septic cerebral embolism. A total of 4,917 patients were included in the analysis, with 3,909 (79.5 percent) without preoperative septic cerebral embolism and 1,008 (20.5 percent) patients with preoperative septic cerebral embolism. Among patients with preoperative cerebral embolism, 286 (28.4 percent) patients had no stroke signs (silent stroke). There were no statistically significant differences in 30-day mortality (20.1 percent vs. 22.8 percent; p = 0.14) or 5-year survival (47.8 percent vs. 49.1 percent; stratified log-rank p = 0.77) between patients with and without preoperative cerebral embolism. Therefore, the authors conclude that preoperative septic cerebral embolism should not be a major factor in deciding whether to perform surgery in patients with IE requiring heart valve surgery. 

Source: The Journal of Thoracic and Cardiovascular Surgery Open
Author(s): Harry Etienne, Bianca Battilana, Jonathan Spicer, Raphael S. Werner, Isabelle Opitz

This article explores the complexities of determining resectability in patients with non-small cell lung cancer (NSCLC). The authors emphasize that resectability, crucial for deciding treatment pathways, is best assessed by a multidisciplinary tumor board but lacks a standardized definition across clinical guidelines and trials. They discuss the significance of achieving complete resection (R0) for improving survival outcomes and detail the importance of precise staging through advanced imaging and invasive techniques. The article also examines the impact of new induction therapies, such as immune checkpoint inhibitors, on downstaging tumors to achieve resectability. This topic is highly relevant to CTSNet’s global cardiothoracic surgery audience as it addresses evolving surgical strategies and collaborative decision-making essential for optimizing patient outcomes in lung cancer treatment. 

Source: The Journal of Thoracic and Cardiovascular Surgery Open
Author(s): Adham Ahmed, John A. Treffalls, Cameron Best, Gianna J. Dafflisio, Samantha Xu, Lena E. Trager, Sarin N. Paluri, Andrew Jones, George Olverson, Aakash M. Shah, Austin L. Hingtgen, Samantha Colon, Jason J. Han, David Blitzer, Rohun Bhagat, Sara J. Pereira, Irbaz Hameed

This article provides a comprehensive guide for students aiming to enter the field of cardiothoracic surgery, by addressing challenges from premedical stages to residency. This article helps students make informed decisions by detailing various training pathways, including the traditional path, the integrated six-year program, and the fast-track 4+3 pathway. Emphasizing the importance of mentorship, networking, and extracurricular activities such as research and volunteering, the article offers practical advice to build a competitive application. It also discusses future opportunities within the specialty, such as super-fellowships and diverse career paths. This guide is crucial for aspiring cardiothoracic surgeons, demystifying the path to a demanding field and addressing workforce shortages. It is particularly relevant to CTSNet’s global audience, highlighting strategies for success in a competitive and evolving specialty. 

Source: The Journal of Thoracic and Cardiovascular Surgery Techniques
Author(s): Mohammad Alomari, Pankaj Garg, Nafiye Busra Celik, J. Ross Renew, Basar Sareyyupoglu

Persistent left superior vena cava (PLSVC) encountered during heart transplant in either the donor or the recipient is highly unusual and significantly complicates the operation. Several options exist to manage this condition, including the use of a prosthetic graft that reconstructs the anatomy by linking the PLSVC to the right atrium, with different areas of placement of the conduit itself. The authors share a novel technique that avoids the use of prosthetic material, simplifies this operation, reduces cardiopulmonary bypass time, and is reproducible. The technique involves using a modified cardiectomy that unifies the recipient coronary sinus and inferior vena cava followed by anastomosis of this structure to the donor inferior vena cava en bloc.

Source: European Journal of Cardio-Thoracic Surgery
Author(s): Hsun-Yi Fu, Yih-Sharng Chen, Hsi-Yu Yu, Nai-Hsin Chi, Ling-Yi Wei, Kevin Po-Hsun Chen, Heng-Wen Chou, Nai-Kuan Chou, Chih-Hsien Wang

The optimal revascularization strategy after extracorporeal cardiopulmonary resuscitation (ECPR) remains unclear, with limited existing data. This study compared outcomes for patients who underwent coronary artery bypass grafting (CABG) and those who received percutaneous coronary intervention (PCI) after ECPR using databases from two referral centers. Forty patients in each category were compared. Researchers found that the CABG group had better early outcomes (hospital survival- 56.4 percent vs 32.4 percent, p = 0.04 and success of ECPR weaning: 71.1 percent vs 48.7 percent, p = 0.05) compared to the PCI group. Late outcomes were similar among groups, although the PCI group appeared to have more endovascular interventions.

Source: The Journal of Heart and Lung Transplantation
Author(s): Margareta Mittendorfer, Leif Pierre, Tibor Huzevka, Jeremy Schofield, Simon T. Abrams, Guozheng Wang, Cheng-Hock Toh, Nicholas B. Bèchet, Ilma Caprnja, Gunilla Kjellberg, Andrew Aswani, Franziska Olm, Sandra Lindstedt

Lung transplantation is limited by the availability of donors, with relative scarcity of organs. Aspiration prior to donation is one reason donor organs might be discarded due to concern for acute lung injury, which adversely impacts graft survival. This cellular injury is mediated by neutrophil extracellular traps (NETs), and removal of these inflammatory structures has been postulated to reduce aspiration associated with cellular injury. This article studied a NET removal device in porcine lungs and found lower inflammatory markers including cytokines, cell free DNA, and tissue edema. This article aims to potentially increase the transplant lung donor pool by highlighting this area of study.  

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