In this manuscript, the authors offer a comprehensive and thorough review of the pathophysiology of aortic stenosis and relate this to the different potential medical treatment options to slow down the progression of the disease.
ALERT!
This site is not optimized for Internet Explorer 8 (or older).
Please upgrade to a newer version of Internet Explorer or use an alternate browser such as Chrome or Firefox.
Cardiac - Pharmacology
November 1, 2016
An interesting case series of cardiotoxicity of modern chemotherapy attempting to elucidate mechanisms of heart failure.
July 13, 2016
This retrospective study evaluated the effects of high-dose nitroglycerine (NTG) on glucose metabolism, tissue oxygenation and postoperative recovery in cardiac surgical patients. Two groups were classified: NTG group (iv loading of NTG starting at rewarming of cardiopulmonary bypass; n=101), NON-NTG group (n=151).
May 8, 2016
The entire issue is dedicated to thrombosis and makes a compulsory read for cardiovascular and thoracic hospitalists. Of patricular relevance to the thoracic surgeon are the translational articles on system analysis (page 1348) and the table on oral anticoagulants on page 1410.
March 27, 2016
Norepinephrine is often used to maintain the mean pressure during open heart surgery but it is said that it could constrict cerebral arteries, reducing cerebral blood flow. Is it true? The authors explored the association of Norepi doses and rSO2 measured using near-infrared spectroscopy.
February 2, 2016
This randomized trial (NEAT-HFpEF) of 110 subjects (59 placebos) disproves, by clinical and biological markers, the utility of nitrates for exercise tolerance. This is a subset of cardiac failure patients we are likely to encounter in general cardiothoracic surgical practice.
November 11, 2015
The timing and dosage of preoperative ASA administration was evaluated with regard to CABG outcomes in a series of 3018 pts. Dosing within 24 hrs of surgery was associated with a 50% lower mortality rate and an 81mg dose was associated with a 50% or greater reduction in mortality compared to a 325mg dose or no ASA.
September 26, 2015
In this RCT, patients at increased risk for cardiac surgery requiring CPB were assigned to steroids at the time of anesthetic induction and again at the time of CPB induction or no steroids. Primary outcomes were 30-day mortality and major morbidity. Steriods had no effect on the primary outcomes. There was no evidence that stero
May 17, 2015
The question of whether digoxin increases the risk of death in patients with atrial fibrillation (AF) or congestive heart failure (CHF) continues to be a matter of debate. The authors of this manuscript attempt to find an answer with a meta-analysis and systematic review of the literature.
March 16, 2015
In this manuscript the authors present a post-hoc study of the SYNTAX trial. They compare outcomes between those patients on optimal medical therapy (OMT) and non-optimal medical therapy following revascularization for complex coronary artery disease (CAD).