Concerns remain about the definition of a high risk population who can benefit from low-dose computed tomography screening programs.
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Lung Cancer - Genetics
November 12, 2014
This study was conducted in 94 lung adenocarcinoma patients matching pairs from current, former and never smokers' lung adenocarcinoma and non-malignant lung parenchymal tissue. Investigators discovered different smoking-specific microRNA differences.
Transcriptomic Architecture of the Adjacent Airway Field Cancerization in Non–Small Cell Lung Cancer
April 14, 2014
In this promising investigation, authors have found changes associated with airway cancerization in large airways in lung cancer patients, while these changes are absent in cancer-free smokers. And in addition, with shorter distance from tumors, airway cancerization expression increases statistically.
March 8, 2014
In an effort to provide diagnostic information complementary to radiographic screening for lung cancer, the authors evaluated the diagnostic performance of plasma mRNA. The mRNA signature classifier demonstrated 87% sensitivity and 81% specificity, with a negative predictive value of 99%. In contrast, low dose CT had a sensitivity of 79% and a spec
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