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Journal and News Scan
September 17, 2015
Submitted by: CTSNet Staff
Perhexilene modulates cardiac metabolism and is expected to provide myocardial protection during cardiac surgery in patients with left ventricular hypertrophy. The agent was tested in a randomized clinical trial and administered per os preoperatively. The primary endpoint was use of inotropics for low cardiac output. The trial was halted after analysis of 110 of 220 planned patients due to the lack of difference between the groups for the primary and also for secondary endpoints.
September 17, 2015
Submitted by: CTSNet Staff
The authors describe the tricks and traps of minimally invasive approach during VAD implantation, by associating mini anterior left thoracotomy in the fifth intercostal space with a mini anterior right thoracotomy in the second intercostal space, without the aid of CPB in paravertebral block regional analgesia combined with mild general anaesthesia.
September 17, 2015
Submitted by: CTSNet Staff
Arthur Caplan of the Division of Medical Ethics at NYU Langone Medical center poses a difficult ethical question: how many hearts should one child receive? Dr. Caplan presents the case of a young patient who recently received a third heart transplant.
September 16, 2015
Submitted by: Mark Ferguson
No guidelines for credentialling ECMO physicians exist, so the authors surveyed ECMO programs to determine what institutional credentialling mechanisms consist of. The survey response rate was 42%. 66% of institutions require credentialling, 57% of institutions had credentialling mechanisms, and yearly recertification was required in 16%.
September 16, 2015
Submitted by: Mark Ferguson
Outcomes of the California Cancer Registry for patients undergoing resection for Stage I NSCLC were evaluated according to Commission on Cancer (CoC) accreditation status and lung resection procedure volume. High volume hospitals (>50 annually) had better survival compared to medium (20-50 annually; HR 1.23) and low volume (<20 annually; 1.77) hospitals. Survival was not associated with CoC status.
September 16, 2015
Submitted by: Mark Ferguson
The 6th and 7th versions of the AJCC staging system were compared for their prognostic accuracy for patients with esophagogastric adenocarcinomas using an institutional database. The 7th edition system was significantly more accurate in groups undergoing MIE, induction therapy, and overall.
September 12, 2015
Submitted by: Mark Ferguson
This randomized trial compared induction therapy for pathologically-proven N2/IIIA NSCLC with 3 cycles of cisplatinum and docetaxel chemotherapy alone to chemotherapy combined with 44 Gy of radiation therapy. 232 pts in 23 centers were enrolled over a 12 year period. No differences were identified in the chemotherapy vs chemoradiotherapy groups for event-free survival (11.6 vs 12.8 mos) or median survival (26.2 vs 37.1).
Comparative Histology of Aortic Dilatation Associated With Bileaflet Versus Trileaflet Aortic Valves
September 9, 2015
Submitted by: Arie Blitz
Resected aortas associated with a bicuspid aortic valve (BAV,n = 60) and trileaflet aortic valve (n = 24) in patients with aortic valve disease were compared with normal diameter aortas from patients undergoing cardiac transplantation (n = 16) by five histologic criteria. The extent of elastic fiber loss, smooth muscle cell loss, medial fibrosis, and atherosclerosis was more severe in trileaflet aortic valve than BAV when considered across all diameters and when stratified to those between 4 and 5 cm. This finding begs the question: Should the guideline-recommended more aggressive threshold for replacing the aorta in BAV patients as compared to trileaflet aortic valve patients be revisited?
September 8, 2015
Submitted by: Mark Ferguson
This single institution study involving 606 patients operated 2000-2012 examined the influence of the extent of lymphadenectomy on survival. The number of nodes resected was not related to all-cause mortality, even comparing the highest and lowest quartiles. The number of metastatic nodes and an increasing ratio of positive to negative nodes were each related to increasing mortality rates in a dose-response relationship.
September 5, 2015
Submitted by: Mark Ferguson
The consequences of the flawed process of investigation of scientific misconduct and premature conclusions of the outcomes are discussed.